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Query: TNKS

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TNKS 0 0.509 0.420 0.660

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TNKS Ubiquitylation K1081 -0.151 _LIK(gl)GVER_
TNKS Ubiquitylation K667 -0.766 -0.164 _AGDLETVK(gl)QLCSSQNVNCR_
TNKS Ubiquitylation K771 -1.280 _LLLK(gl)HGADPTKK_
TNKS Ubiquitylation K762 -1.426 _GK(gl)YEICK_
TNKS Ubiquitylation K812 -0.176 -1.693 _GDAALLDAAK(gl)K_
TNKS Ubiquitylation K813 -0.176 -1.693 _GDAALLDAAK(gl)K_

Background Information for TNKS:


Pubmed-TNKS »
Uniprot-TNKS »
Biogrid-TNKS »
ProteomicsDB-TNKS »

Tumorportal-TNKS »
COSMIC-TNKS »
GenomeRNAi-TNKS »
Genecards-TNKS


Protein-protein Interactions for TNKS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BLZF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF20A Cat. description Hein, Mann, Cell 2015
Category members IP bait TERF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNKS Cat. description Hein, Mann, Cell 2015
Category members IP bait TNKS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BABAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BLZF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CELF5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CEP170 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CHD1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM117B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GMDS Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIF1AN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLRG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LRP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPK8IP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RNF166 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RTN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SH3BP5L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SLC35A5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSSCA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TERF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TINF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM44 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TNKS
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SAM IPR001660 0
Category members Ankyrin_rpt IPR002110 0
Category members SAM_2 IPR011510 0
Category members Poly(ADP-ribose)pol_cat_dom IPR012317 0
Category members SAM/pointed IPR013761 0
Category members Ankyrin_rpt-contain_dom IPR020683 0
Category members SAM_type1 IPR021129 0


Protein complexes (CORUM database) featuring TNKS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1202 TRF1 telomere length regulation complex Database 0
Category members Corum 1206 TRF-Rap1 complex I, 2MD Database 0
Category members Corum 1219 Tankyrin 1-tankyrin 2-TRF1 complex Database 0


Categories featuring TNKS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005643 nuclear pore Database 6.58
Category members GO Category GO:0015031 protein transport Database 3.48
Category members Pathway Pathway_881 PID_TELOMERASE_PATHWAY 0 2.64
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0051028 mRNA transport Database 1.7
Category members Pathway Pathway_366 BIOCARTA_TEL_PATHWAY 0 1.44
Category members GO Category GO:0000784 nuclear chromosome, telomeric region Database 0.61
Category members GO Category GO:0007052 mitotic spindle organization Database 0.41
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0051225 spindle assembly Database 0.25
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0000781 chromosome, telomeric region Database 0.16
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0070212 protein poly-ADP-ribosylation Database 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0032212 positive regulation of telomere maintenance via telomerase Database 0.02
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members GO Category GO:0018107 peptidyl-threonine phosphorylation Database 0.01
Category members GO Category GO:0000139 Golgi membrane Database 0
Category members GO Category GO:0000242 pericentriolar material Database 0
Category members GO Category GO:0003950 NAD+ ADP-ribosyltransferase activity Database 0
Category members GO Category GO:0006471 protein ADP-ribosylation Database 0
Category members GO Category GO:0070198 protein localization to chromosome, telomeric region Database 0
Category members GO Category GO:0070213 protein auto-ADP-ribosylation Database 0


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