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Query: TNIK

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TNIK 2 7.009 -2.250 5.030 -0.852 -0.525
TNIK 2 7.009 -2.250 5.030 0.038 0.092 0.062

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TNIK Phosphorylation S954 1.646 _VSTHS(ph)QEMDSGTEYGMGSSTK_
TNIK Phosphorylation S680 0.363 0.497 _TTSIS(ph)PALAR_
TNIK Phosphorylation S707 0.024 -0.032 _LGSQPIRAS(ph)NPDLR_
TNIK Phosphorylation S764 0.214 -0.395 _ANS(ph)KS(ph)EGSPVLPHEPAK_
TNIK Phosphorylation S766 -0.772 -0.395 _S(ph)EGSPVLPHEPAK_
TNIK Phosphorylation S769 -0.527 -0.660 _SEGS(ph)PVLPHEPAK_
TNIK Ubiquitylation K824 -0.222 _IEETNRPMK(gl)K_

Background Information for TNIK:


Pubmed-TNIK »
Uniprot-TNIK »
Biogrid-TNIK »
ProteomicsDB-TNIK »

Tumorportal-TNIK »
COSMIC-TNIK »
GenomeRNAi-TNIK »
Genecards-TNIK


Protein-protein Interactions for TNIK
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait IL20RA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LTBR Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MRPS11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TNIK
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Citron IPR001180 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring TNIK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring TNIK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members GO Category GO:0031532 actin cytoskeleton reorganization Database 0.29
Category members GO Category GO:0055037 recycling endosome Database 0.29
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0004702 receptor signaling protein serine/threonine kinase activity Database 0.1
Category members GO Category GO:0007256 activation of JNKK activity Database 0.1
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_738 PID_TNF_PATHWAY 0 0
Category members GO Category GO:0005083 small GTPase regulator activity Database 0
Category members GO Category GO:0007010 cytoskeleton organization Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0035556 intracellular signal transduction Database 0
Category members GO Category GO:0048814 regulation of dendrite morphogenesis Database 0


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