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Query: TLE4

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
TLE4 0 1.878 -0.380 0.600
TLE4 0 1.878 -0.380 0.600 0.116

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
TLE4 Phosphorylation S208 0.427 0.632 _SSSVS(ph)PSASFR_
TLE4 Phosphorylation S286 0.242 0.160 _DASSS(ph)PASTASSASSTSLK_
TLE4 Phosphorylation S292 -0.214 -0.084 _DAPIS(ph)PASIASSSSTPSSK_
TLE4 Phosphorylation S206 0.530 _SSS(ph)VSPSASFR_

Background Information for TLE4:


Pubmed-TLE4 »
Uniprot-TLE4 »
Biogrid-TLE4 »
ProteomicsDB-TLE4 »

Tumorportal-TLE4 »
COSMIC-TLE4 »
GenomeRNAi-TLE4 »
Genecards-TLE4


Protein-protein Interactions for TLE4
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CCT7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HLX Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1984 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIPPLY1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RIPPLY2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TBX20 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLE3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TLE4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TNNI2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VENTX Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in TLE4
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members WD40_repeat_dom IPR017986 1.39
Category members WD40_repeat IPR001680 0.52
Category members Groucho/TLE_N IPR005617 0
Category members Groucho_enhance IPR009146 0


Protein complexes (CORUM database) featuring TLE4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 3149 NK-3-Groucho-HIPK2-SIN3A-RbpA48-HDAC1 complex Database 0.04
Category members Corum 3121 OCT2-TLE4 complex Database 0
Category members Corum 3127 TLE-Histone H3 complex Database 0
Category members Corum 3150 NK-3-Groucho complex Database 0


Categories featuring TLE4
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Pathway Pathway_199 PID_BETA_CATENIN_NUC_PATHWAY 0 0.53
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members Pathway Pathway_824 REACTOME_NOTCH1_INTRACELLULAR_DOMAIN_REGULATES_TRANSCRIPTION 0 0.14
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0003674 molecular_function Database 0.08
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members Pathway Pathway_489 PID_NFAT_TFPATHWAY 0 0
Category members GO Category GO:0003705 RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Database 0
Category members GO Category GO:0003714 transcription corepressor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0008150 biological_process Database 0
Category members GO Category GO:0070491 repressing transcription factor binding Database 0


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