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Query: SYNE1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SYNE1 0 4.138 -0.990 2.410 0.468

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SYNE1 Phosphorylation S8305 0.804 0.456 _ALPS(ph)EDEEGQDDKDFYLR_
SYNE1 Phosphorylation T8360 0.406 0.397 _SKT(ph)PTGPELDTSYK_

Background Information for SYNE1:


Pubmed-SYNE1 »
Uniprot-SYNE1 »
Biogrid-SYNE1 »
ProteomicsDB-SYNE1 »

Tumorportal-SYNE1 »
COSMIC-SYNE1 »
GenomeRNAi-SYNE1 »
Genecards-SYNE1


Protein-protein Interactions for SYNE1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait TRIM29 Cat. description Hein, Mann, Cell 2015
Category members IP bait IFT57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SYNE1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members CH-domain IPR001715 0.63
Category members KASH IPR012315 0.52
Category members ABC1_TM_dom IPR011527 0.33
Category members tRNA-bd_arm IPR010978 0.08
Category members Calpain_domain_III IPR022682 0


Protein complexes (CORUM database) featuring SYNE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SYNE1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0003779 actin binding Database 5.41
Category members GO Category GO:0031965 nuclear membrane Database 2.59
Category members Disease phenotype Autosomal_dominant_Emery-Dreifuss_muscular_dystrophy Autosomal dominant Emery-Dreifuss muscular dystrophy Database 0.89
Category members GO Category GO:0005521 lamin binding Database 0.75
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0034993 SUN-KASH complex Database 0.28
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0005640 nuclear outer membrane Database 0.18
Category members GO Category GO:0006997 nucleus organization Database 0.18
Category members GO Category GO:0007030 Golgi organization Database 0.13
Category members GO Category GO:0055085 transmembrane transport Database 0.12
Category members GO Category GO:0042692 muscle cell differentiation Database 0.1
Category members GO Category GO:0042626 ATPase activity, coupled to transmembrane movement of substances Database 0.09
Category members GO Category GO:0008219 cell death Database 0.08
Category members GO Category GO:0030017 sarcomere Database 0.06
Category members GO Category GO:0045211 postsynaptic membrane Database 0.06
Category members GO Category GO:0006810 transport Database 0
Category members GO Category GO:0042803 protein homodimerization activity Database 0


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