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Query: SYMPK

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SYMPK 0 2.979 -0.610 1.280 -0.489 0.051 -0.040 -0.388 0.104

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SYMPK Ubiquitylation K1040 0.447 0.966 _VWEGFIK(gl)CCQR_
SYMPK Phosphorylation S501 0.517 -0.005 _RLSAQGQAIS(ph)VVGSLSSMSPLEEEAPQAK_
SYMPK Phosphorylation S1171 -0.647 -0.147 _LKPGGVGAPSSSS(ph)PSPSPSAR_
SYMPK Phosphorylation T1231 0.104 -0.160 _ET(ph)AAGGLTLKEERSPQTLAPVGEDAMK_
SYMPK Phosphorylation S494 0.456 -0.279 _RLS(ph)AQGQAISVVGSLSSMSPLEEEAPQAK_
SYMPK Phosphorylation S1243 0.014 -0.294 _S(ph)PQTLAPVGEDAM(ox)K_
SYMPK Ubiquitylation K490 -0.556 -1.231 _TESVLIK(gl)R_
SYMPK Phosphorylation S1259 -0.172 -1.286 _TPS(ph)PAAEDAREPEAK_
SYMPK Phosphorylation S1173 1.053 -2.091 _LKPGGVGAPSSSSPS(ph)PSPSAR_
SYMPK Ubiquitylation K551 -0.114 _LSDVLK(gl)PLTDAQVEAMK_
SYMPK Phosphorylation S1170 -0.325 _LKPGGVGAPSSS(ph)SPSPSPSAR_
SYMPK Phosphorylation T1237 0.076 _ETAAGGLT(ph)LKEERSPQTLAPVGEDAM(ox)K_

Background Information for SYMPK:


Pubmed-SYMPK »
Uniprot-SYMPK »
Biogrid-SYMPK »
ProteomicsDB-SYMPK »

Tumorportal-SYMPK »
COSMIC-SYMPK »
GenomeRNAi-SYMPK »
Genecards-SYMPK


Protein-protein Interactions for SYMPK
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CPSF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait FIP1L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ID2 Cat. description Hein, Mann, Cell 2015
Category members IP bait KLC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MKNK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYMPK Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS26A Cat. description Hein, Mann, Cell 2015
Category members IP bait BSG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf75 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPEB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPSF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSTF2T Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KLHDC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LYPD3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SYMPK
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26


Protein complexes (CORUM database) featuring SYMPK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 1147 Polyadenylation complex (CSTF1, CSTF2, CSTF3, SYMPK CPSF1, CPSF2, CPSF3) Database 0


Categories featuring SYMPK
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005488 binding Database 9.32
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005923 tight junction Database 0.69
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0006378 mRNA polyadenylation Database 0.1
Category members GO Category GO:0006398 histone mRNA 3'-end processing Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0035307 positive regulation of protein dephosphorylation Database 0


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