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Query: STXBP1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
STXBP1 0 4.047 -0.320 0.260
STXBP1 0 4.047 -0.320 0.260 0.349 0.605

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
STXBP1 Phosphorylation S545 0.985 _ESS(ph)RVSFEDQAPTM(ox)E_
STXBP1 Ubiquitylation K333 0.650 _DLSQMLKK(gl)_
STXBP1 Ubiquitylation K321 1.198 0.167 _MNTGEK(gl)TTMR_
STXBP1 Ubiquitylation K184 -0.088 _LAEQIATLCATLK(gl)EYPAVR_
STXBP1 Ubiquitylation K314 1.042 _SLKDFSSSK(gl)R_
STXBP1 Ubiquitylation K332 0.879 _DLSQMLK(gl)K_

Background Information for STXBP1:


Pubmed-STXBP1 »
Uniprot-STXBP1 »
Biogrid-STXBP1 »
ProteomicsDB-STXBP1 »

Tumorportal-STXBP1 »
COSMIC-STXBP1 »
GenomeRNAi-STXBP1 »
Genecards-STXBP1


Protein-protein Interactions for STXBP1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait DNAJC11 Cat. description Hein, Mann, Cell 2015
Category members IP bait FERMT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ID1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PHOSPHO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PLK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SART3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ARMC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C14orf104 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDCA8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DGUOK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GJA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPRC5B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NUFIP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RRP7A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TM4SF18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TUSC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in STXBP1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Sec1-like IPR001619 1.02


Protein complexes (CORUM database) featuring STXBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring STXBP1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0015031 protein transport Database 3.48
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0047485 protein N-terminus binding Database 1.84
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_5 REACTOME_INTEGRATION_OF_ENERGY_METABOLISM 0 0.9
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members GO Category GO:0006904 vesicle docking involved in exocytosis Database 0.51
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0007268 synaptic transmission Database 0.23
Category members GO Category GO:0006112 energy reserve metabolic process Database 0.21
Category members GO Category GO:0006887 exocytosis Database 0.2
Category members GO Category GO:0010807 regulation of synaptic vesicle priming Database 0.17
Category members GO Category GO:0045956 positive regulation of calcium ion-dependent exocytosis Database 0.16
Category members Pathway Pathway_270 REACTOME_REGULATION_OF_INSULIN_SECRETION 0 0.09
Category members GO Category GO:0017075 syntaxin-1 binding Database 0.09
Category members Pathway Pathway_1264 REACTOME_DOPAMINE_NEUROTRANSMITTER_RELEASE_CYCLE 0 0.07
Category members GO Category GO:0050796 regulation of insulin secretion Database 0.06
Category members Disease phenotype Nonspecific_severe_ID Nonspecific severe ID Database 0.06
Category members GO Category GO:0000149 SNARE binding Database 0.05
Category members GO Category GO:0019905 syntaxin binding Database 0.05
Category members GO Category GO:0070527 platelet aggregation Database 0.05
Category members GO Category GO:0050821 protein stabilization Database 0.04
Category members Pathway Pathway_389 REACTOME_GABA_SYNTHESIS_RELEASE_REUPTAKE_AND_DEGRADATION 0 0.04
Category members Pathway Pathway_404 REACTOME_NOREPINEPHRINE_NEUROTRANSMITTER_RELEASE_CYCLE 0 0.04
Category members Pathway Pathway_397 REACTOME_GLUTAMATE_NEUROTRANSMITTER_RELEASE_CYCLE 0 0.01
Category members Pathway Pathway_139 REACTOME_NEURONAL_SYSTEM 0 0
Category members Pathway Pathway_140 REACTOME_TRANSMISSION_ACROSS_CHEMICAL_SYNAPSES 0 0
Category members Pathway Pathway_390 REACTOME_NEUROTRANSMITTER_RELEASE_CYCLE 0 0
Category members Pathway Pathway_712 REACTOME_ACETYLCHOLINE_NEUROTRANSMITTER_RELEASE_CYCLE 0 0
Category members Disease phenotype DRAVET_SYNDROME DRAVET SYNDROME Database 0
Category members Disease phenotype Early_infantile_epileptic_encephalopathy Early infantile epileptic encephalopathy Database 0
Category members GO Category GO:0002576 platelet degranulation Database 0
Category members GO Category GO:0007269 neurotransmitter secretion Database 0
Category members GO Category GO:0007274 neuromuscular synaptic transmission Database 0
Category members GO Category GO:0007412 axon target recognition Database 0
Category members GO Category GO:0014047 glutamate secretion Database 0
Category members GO Category GO:0016188 synaptic vesicle maturation Database 0
Category members GO Category GO:0031091 platelet alpha granule Database 0
Category members GO Category GO:0032229 negative regulation of synaptic transmission, GABAergic Database 0
Category members GO Category GO:0045921 positive regulation of exocytosis Database 0
Category members GO Category GO:0060292 long term synaptic depression Database 0


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