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Query: SRRM1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SRRM1 1 0.796 0.510 -1.020 -2.536 -0.548 -0.106

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SRRM1 Phosphorylation S391 0.670 1.010 _RLS(ph)PS(ph)ASPPR_
SRRM1 Phosphorylation S463 2.082 0.890 _KVELSES(ph)EEDKGGK_
SRRM1 Phosphorylation S461 0.912 0.886 _KVELS(ph)ESEEDKGGK_
SRRM1 Phosphorylation T884 0.984 0.756 _KET(ph)ES(ph)EAEDNLDDLEK_
SRRM1 Phosphorylation S886 0.612 0.556 _KET(ph)ES(ph)EAEDNLDDLEK_
SRRM1 Phosphorylation S752 0.546 0.509 _KAAS(ph)PS(ph)PQSVR_
SRRM1 Phosphorylation S725 0.842 0.451 _RQS(ph)PSPSTRPIR_
SRRM1 Phosphorylation S750 0.336 0.368 _AAS(ph)PSPQSVR_
SRRM1 Phosphorylation S609 0.257 0.339 _RYS(ph)PPIQR_
SRRM1 Phosphorylation S234 0.189 0.288 _VKEPS(ph)VQEATSTSDILK_
SRRM1 Phosphorylation S393 0.180 0.278 _RLS(ph)PSAS(ph)PPR_
SRRM1 Phosphorylation S550 0.523 0.207 _RWQS(ph)PVTK_
SRRM1 Phosphorylation S727 0.068 0.089 _RQSPS(ph)PSTRPIR_
SRRM1 Ubiquitylation K36 -0.052 _FAECLEK(gl)K_
SRRM1 Ubiquitylation K37 0.946 -0.052 _FAECLEKK(gl)_
SRRM1 Phosphorylation T730 -0.345 -0.119 _RQSPSPST(ph)RPIR_
SRRM1 Phosphorylation S617 -0.202 -0.195 _RYS(ph)PS(ph)PPPK_
SRRM1 Phosphorylation T220 -0.236 -0.247 _T(ph)PELPEPSVK_
SRRM1 Phosphorylation S729 0.141 -0.253 _QS(ph)PSPS(ph)TRPIRR_
SRRM1 Phosphorylation S450 -0.294 _RESPS(ph)PAPKPR_
SRRM1 Phosphorylation S448 -0.669 -0.441 _RES(ph)PSPAPKPR_
SRRM1 Phosphorylation S402 -0.216 -0.477 _HRPS(ph)PPAT(ph)PPPK_
SRRM1 Phosphorylation S708 -0.506 -0.481 _APQTSSS(ph)PPPVRR_
SRRM1 Phosphorylation S707 -0.548 -0.489 _APQTSS(ph)SPPPVR_
SRRM1 Phosphorylation S389 0.530 -0.508 _RLS(ph)PS(ph)ASPPR_
SRRM1 Phosphorylation S706 -0.527 -0.615 _APQTS(ph)SSPPPVRR_
SRRM1 Phosphorylation S619 -0.637 -0.652 _RYS(ph)PS(ph)PPPK_
SRRM1 Phosphorylation S628 -0.806 -0.787 _T(ph)AS(ph)PPPPPK_
SRRM1 Phosphorylation S789 -0.821 _KPPAPPS(ph)PVQSQSPS(ph)TNWSPAVPVKK_
SRRM1 Phosphorylation T626 -1.225 -0.870 _T(ph)AS(ph)PPPPPK_
SRRM1 Phosphorylation S781 -1.190 -1.298 _KPPAPPS(ph)PVQSQSPSTNWSPAVPVK_
SRRM1 Phosphorylation S785 -1.558 -1.554 _KPPAPPS(ph)PVQS(ph)QSPSTNWSPAVPVK_
SRRM1 Phosphorylation S787 -0.948 -1.602 _KPPAPPS(ph)PVQSQS(ph)PSTNWSPAVPVK_
SRRM1 Phosphorylation T406 -1.669 -1.607 _HRPS(ph)PPAT(ph)PPPK_
SRRM1 Phosphorylation S260 -1.874 -1.702 _VPKPEPIPEPKEPS(ph)PEK_

Background Information for SRRM1:


Pubmed-SRRM1 »
Uniprot-SRRM1 »
Biogrid-SRRM1 »
ProteomicsDB-SRRM1 »

Tumorportal-SRRM1 »
COSMIC-SRRM1 »
GenomeRNAi-SRRM1 »
Genecards-SRRM1


Protein-protein Interactions for SRRM1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MTX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH7B Cat. description Hein, Mann, Cell 2015
Category members IP bait SMCHD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNCA Cat. description Hein, Mann, Cell 2015
Category members IP bait SRSF1 Cat. description Hein, Mann, Cell 2015
Category members IP bait VPS18 Cat. description Hein, Mann, Cell 2015
Category members IP bait C11orf57 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLK2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1T Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MKI67IP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDGFB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBM34 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RPL18A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRA2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZC3H18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF22 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SRRM1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PWI_dom IPR002483 0


Protein complexes (CORUM database) featuring SRRM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 1183 CDC5L complex Database 2.07
Category members Corum 5449 Splicing-associated factors complex Database 0.5
Category members Corum 785 Exon junction complex Database 0.29
Category members Corum 1261 SRm160/300 complex Database 0.02
Category members Corum 1195 Exon junction complex (mRNA splicing-dependent) Database 0
Category members Corum 2833 SRm160-SRm300 complex Database 0


Categories featuring SRRM1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members Pathway Pathway_878 REACTOME_TRANSPORT_OF_MATURE_TRANSCRIPT_TO_CYTOPLASM 0 6.53
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0006406 mRNA export from nucleus Database 4.09
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members Pathway Pathway_852 REACTOME_MRNA_3_END_PROCESSING 0 2.02
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_854 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 0 0.91
Category members GO Category GO:0031124 mRNA 3'-end processing Database 0.91
Category members GO Category GO:0006369 termination of RNA polymerase II transcription Database 0.87
Category members GO Category GO:0000375 RNA splicing, via transesterification reactions Database 0.73


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