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Query: SRPRB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SRPRB 0 1.098 0.920 -0.400 -0.155 -0.328 0.005

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SRPRB Ubiquitylation K191 -0.160 0.940 _SAK(gl)LIQQQLEK_
SRPRB Phosphorylation T214 0.004 0.792 _SAAPST(ph)LDSSSTAPAQLGK_
SRPRB Ubiquitylation K227 0.280 _SAAPSTLDSSSTAPAQLGK(gl)K_
SRPRB Ubiquitylation K228 -1.460 0.280 _SAAPSTLDSSSTAPAQLGKK(gl)_

Background Information for SRPRB:


Pubmed-SRPRB »
Uniprot-SRPRB »
Biogrid-SRPRB »
ProteomicsDB-SRPRB »

Tumorportal-SRPRB »
COSMIC-SRPRB »
GenomeRNAi-SRPRB »
Genecards-SRPRB


Protein-protein Interactions for SRPRB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ATL3 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP7A Cat. description Hein, Mann, Cell 2015
Category members IP bait BATF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BAZ2B Cat. description Hein, Mann, Cell 2015
Category members IP bait BMPR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait FAM46A Cat. description Hein, Mann, Cell 2015
Category members IP bait GET4 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITGB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KATNA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCSTN Cat. description Hein, Mann, Cell 2015
Category members IP bait SRPR Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait TNPO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP2B2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHEB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SRPRB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SRPRB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members EF_GTP-bd_dom IPR000795 1.57
Category members Small_GTPase_ARF/SAR IPR006689 0.8
Category members Gtr1_RagA IPR006762 0.63
Category members SRP_receptor_beta_su IPR019009 0.13


Protein complexes (CORUM database) featuring SRPRB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SRPRB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members Pathway Pathway_914 KEGG_PROTEIN_EXPORT 0 0.7
Category members GO Category GO:0016020 membrane Database 0.52
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members Pathway Pathway_148 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S 0 0.11
Category members GO Category GO:0005881 cytoplasmic microtubule Database 0.04


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