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Query: SMC3

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMC3 3 15.773 -0.960 1.470
SMC3 3 15.773 -0.960 1.470 0.213 0.283
SMC3 3 15.773 -0.960 1.470 2.266 0.833 0.442

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMC3 Phosphorylation S1081 3.980 3.931 _GS(ph)GSQSSVPSVDQFTGVGIR_
SMC3 Phosphorylation S1083 4.043 3.766 _GSGS(ph)QSSVPSVDQFTGVGIR_
SMC3 Phosphorylation S1086 3.710 _GSGSQSS(ph)VPSVDQFTGVGIR_
SMC3 Phosphorylation S1085 3.316 _GSGSQS(ph)SVPSVDQFTGVGIR_
SMC3 Phosphorylation S1067 1.197 1.207 _KGDVEGSQS(ph)QDEGEGSGESER_
SMC3 Ubiquitylation K1105 0.634 1.207 _VSFTGK(gl)QGEMR_
SMC3 Ubiquitylation K194 0.447 0.876 _INELLK(gl)YIEER_
SMC3 Ubiquitylation K172 0.044 0.537 _VYDERK(gl)EESISLMK_
SMC3 Ubiquitylation K140 -0.351 0.443 _SNPYYIVK(gl)QGK_
SMC3 Ubiquitylation K143 -1.015 0.329 _QGK(gl)INQMATAPDSQR_
SMC3 Ubiquitylation K106 0.087 _K(gl)DQYFLDKK_
SMC3 Ubiquitylation K180 0.000 _KEESISLM(ox)K(gl)ETEGKR_
SMC3 Ubiquitylation K188 0.711 _EK(gl)INELLK_
SMC3 Ubiquitylation K459 0.122 _YYEVK(gl)NK_
SMC3 Ubiquitylation K461 0.122 _YYEVK(gl)NK_
SMC3 Ubiquitylation K968 1.085 _K(gl)LEQCNTELKK_
SMC3 Ubiquitylation K977 0.607 _KLEQCNTELK(gl)K_
SMC3 Ubiquitylation K1025 0.441 _K(gl)YEAIQLTFK_
SMC3 Ubiquitylation K1034 0.865 _KYEAIQLTFK(gl)QVSK_
SMC3 Ubiquitylation K1038 0.959 _QVSK(gl)NFSEVFQK_
SMC3 Phosphorylation S1065 1.113 _GDVEGS(ph)QSQDEGEGSGESER_
SMC3 Ubiquitylation K1194 0.816 _NK(gl)VSHIDVITAEMAK_

Background Information for SMC3:


Pubmed-SMC3 »
Uniprot-SMC3 »
Biogrid-SMC3 »
ProteomicsDB-SMC3 »

Tumorportal-SMC3 »
COSMIC-SMC3 »
GenomeRNAi-SMC3 »
Genecards-SMC3


Protein-protein Interactions for SMC3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDCA5 Cat. description Hein, Mann, Cell 2015
Category members IP bait RAD21 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC1A Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait WAPAL Cat. description Hein, Mann, Cell 2015
Category members IP bait CDCA5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAD21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDF4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMC3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members RecF/RecN/SMC_N IPR003395 0
Category members SMC_hinge IPR010935 0


Protein complexes (CORUM database) featuring SMC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 282 SNF2h-cohesin-NuRD complex Database 6.11
Category members Corum 163 Cohesin-SA2 complex Database 1.44
Category members Corum 166 Cohesin-SA2 complex Database 1.44
Category members Corum 64 Mitotic 14S cohesin 2 complex Database 1.44
Category members Corum 1856 CDCA5-PDS5A-RAD21-SMC1A-PDS5B-SMC3 complex Database 1.25
Category members Corum 5432 Sororin-cohesin complex Database 1.25
Category members Corum 164 Cohesin-SA1 complex Database 0.62
Category members Corum 165 Cohesin-SA1 complex Database 0.62
Category members Corum 63 Mitotic 14S cohesin 1 complex Database 0.62
Category members Corum 5241 SMC1-SMC3 complex Database 0.38


Categories featuring SMC3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members DDR Literature pubmedid:TBD2_UV_increased Elia et al, 2015 UV increased acetylation events Elia et al. INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_884 REACTOME_MEIOTIC_SYNAPSIS 0 7.46
Category members Pathway Pathway_319 REACTOME_CHROMOSOME_MAINTENANCE 0 7.37
Category members Pathway Pathway_875 REACTOME_MEIOSIS 0 6.39
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_978 PID_ATM_PATHWAY 0 4.31
Category members GO Category GO:0005694 chromosome Database 3.87
Category members Pathway Pathway_223 KEGG_OOCYTE_MEIOSIS 0 2.71
Category members GO Category GO:0000785 chromatin Database 2.59
Category members Pathway Pathway_726 REACTOME_MITOTIC_PROMETAPHASE 0 2.41
Category members GO Category GO:0007067 mitosis Database 2.23
Category members Pathway Pathway_866 KEGG_CELL_CYCLE 0 2.13
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0036033 mediator complex binding Database 1.23
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0032876 negative regulation of DNA endoreduplication Database 1.09
Category members Disease phenotype Cornelia_de_Lange_syndrome Cornelia de Lange syndrome Database 0.87
Category members GO Category GO:0007062 sister chromatid cohesion Database 0.69
Category members GO Category GO:0003777 microtubule motor activity Database 0.49
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0008278 cohesin complex Database 0.44
Category members GO Category GO:0007052 mitotic spindle organization Database 0.41
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0000775 chromosome, centromeric region Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0030893 meiotic cohesin complex Database 0.22
Category members GO Category GO:0006275 regulation of DNA replication Database 0.14
Category members GO Category GO:0034991 nuclear meiotic cohesin complex Database 0.11
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members GO Category GO:0045502 dynein binding Database 0.04
Category members GO Category GO:0007126 meiosis Database 0.01
Category members GO Category GO:0000800 lateral element Database 0
Category members GO Category GO:0005604 basement membrane Database 0
Category members GO Category GO:0007165 signal transduction Database 0


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