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Query: SMC2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMC2 0 0.751 -0.770 1.000
SMC2 0 0.751 -0.770 1.000 -0.048 0.476 -0.227 -0.071
SMC2 0 0.751 -0.770 1.000 0.106

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMC2 Ubiquitylation K1026 0.131 -0.616 _ILTTIEDLDQKK(gl)_

Background Information for SMC2:


Pubmed-SMC2 »
Uniprot-SMC2 »
Biogrid-SMC2 »
ProteomicsDB-SMC2 »

Tumorportal-SMC2 »
COSMIC-SMC2 »
GenomeRNAi-SMC2 »
Genecards-SMC2


Protein-protein Interactions for SMC2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait LIMA1 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPD3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPG2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NCAPH Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC3 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMC4 Cat. description Hein, Mann, Cell 2015
Category members IP bait BMP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C19orf46 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C1QL4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DPEP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EPHA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FZD10 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR137B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LZTS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NCAPH2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SDC2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMC2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members RecF/RecN/SMC_N IPR003395 0
Category members SMC_hinge IPR010935 0


Protein complexes (CORUM database) featuring SMC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 49 DNMT3B complex Database 1.05
Category members Corum 159 Condensin I-PARP-1-XRCC1 complex Database 0.12
Category members Corum 10 13S condensin complex Database 0
Category members Corum 157 Condensin I complex Database 0
Category members Corum 160 Condensin II Database 0
Category members Corum 167 Condensin I complex Database 0
Category members Corum 353 DNA ligase IV-condensin complex Database 0
Category members Corum 5239 CAP(C)-CAP(E) complex Database 0


Categories featuring SMC2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members GO Category GO:0000793 condensed chromosome Database 1.32
Category members GO Category GO:0000228 nuclear chromosome Database 0.89
Category members Pathway Pathway_911 PID_AURORA_B_PATHWAY 0 0.48
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0051276 chromosome organization Database 0.1
Category members GO Category GO:0007076 mitotic chromosome condensation Database 0.01
Category members GO Category GO:0045132 meiotic chromosome segregation Database 0.01
Category members GO Category GO:0000796 condensin complex Database 0
Category members GO Category GO:0010032 meiotic chromosome condensation Database 0
Category members GO Category GO:0051383 kinetochore organization Database 0


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