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Query: SMARCA1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SMARCA1 2 4.756 0.820 0.230 1.940 0.165 0.532 1.513 0.625

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SMARCA1 Ubiquitylation K862 1.344 _LLTQGFTNWTK(gl)R_
SMARCA1 Phosphorylation T118 -0.873 -0.490 _SPT(ph)SPLNMK_

Background Information for SMARCA1:


Pubmed-SMARCA1 »
Uniprot-SMARCA1 »
Biogrid-SMARCA1 »
ProteomicsDB-SMARCA1 »

Tumorportal-SMARCA1 »
COSMIC-SMARCA1 »
GenomeRNAi-SMARCA1 »
Genecards-SMARCA1


Protein-protein Interactions for SMARCA1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C1orf106 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEF6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IDO2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NFATC2IP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RFXANK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM128 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SMARCA1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SNF2_N IPR000330 3.38
Category members P-loop_NTPase IPR027417 2.83
Category members Helicase_C IPR001650 2.48
Category members Helicase_ATP-bd IPR014001 2.48
Category members SANT/Myb IPR001005 2.18
Category members Helicase/UvrB_dom IPR006935 0.78
Category members DEAD/DEAH_box_helicase_dom IPR011545 0.35
Category members ISWI_HAND-dom IPR015194 0.33
Category members SLIDE IPR015195 0.33
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring SMARCA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 100 hNURF complex Database 1.44
Category members Corum 919 hNURF complex Database 1.44
Category members Corum 923 SNF2L-RSF1 complex Database 0.35
Category members Corum 917 CERF complex (CECR2-containing remodeling factor complex) Database 0


Categories featuring SMARCA1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006338 chromatin remodeling Database 4.95
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0004386 helicase activity Database 2.49
Category members GO Category GO:0008094 DNA-dependent ATPase activity Database 2.31
Category members GO Category GO:0016818 hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides Database 1.64
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0043044 ATP-dependent chromatin remodeling Database 1.41
Category members GO Category GO:0016589 NURF complex Database 1.33
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008026 ATP-dependent helicase activity Database 0.79
Category members GO Category GO:0000790 nuclear chromatin Database 0.46
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0031491 nucleosome binding Database 0.24
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0036310 annealing helicase activity Database 0.01
Category members GO Category GO:0000733 DNA strand renaturation Database 0
Category members GO Category GO:0007420 brain development Database 0
Category members GO Category GO:0030182 neuron differentiation Database 0


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