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Query: SIM2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SIM2 0 -0.897 1.780 -1.300

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SIM2 Ubiquitylation K51 -0.897 _LTTSYLK(gl)MR_

Background Information for SIM2:


Pubmed-SIM2 »
Uniprot-SIM2 »
Biogrid-SIM2 »
ProteomicsDB-SIM2 »

Tumorportal-SIM2 »
COSMIC-SIM2 »
GenomeRNAi-SIM2 »
Genecards-SIM2


Protein-protein Interactions for SIM2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ARNT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FOXR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SIM2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PAS_fold_3 IPR013655 0.69
Category members bHLH_dom IPR011598 0.32
Category members PAS_fold IPR013767 0.27
Category members PAC IPR001610 0.23
Category members PAS IPR000014 0.23
Category members SIM_C IPR010578 0.18


Protein complexes (CORUM database) featuring SIM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SIM2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0030324 lung development Database 0.39
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0009880 embryonic pattern specification Database 0
Category members GO Category GO:0046983 protein dimerization activity Database 0


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