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Query: SHMT2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SHMT2 1 2.948 -0.540 1.300 0.878 1.600 -2.560 0.964 0.784

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SHMT2 Ubiquitylation K356 1.096 _EYSLQVLK(gl)NAR_
SHMT2 Ubiquitylation K409 0.692 _VLELVSITANK(gl)NTCPGDR_
SHMT2 Ubiquitylation K469 -0.436 _LQDFK(gl)SFLLK_
SHMT2 Ubiquitylation K103 -2.726 -0.554 _YSEGYPGK(gl)R_
SHMT2 Ubiquitylation K280 -0.564 _HADIVTTTTHK(gl)TLR_
SHMT2 Ubiquitylation K474 -1.113 -0.594 _SFLLK(gl)DSETSQR_

Background Information for SHMT2:


Pubmed-SHMT2 »
Uniprot-SHMT2 »
Biogrid-SHMT2 »
ProteomicsDB-SHMT2 »

Tumorportal-SHMT2 »
COSMIC-SHMT2 »
GenomeRNAi-SHMT2 »
Genecards-SHMT2


Protein-protein Interactions for SHMT2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait ITSN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait NFYC Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TNPO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BABAM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BRE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM175B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SHMT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SHMT2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TMEM184A Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SHMT2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ser_HO-MeTrfase IPR001085 0
Category members PyrdxlP-dep_Trfase IPR015424 0


Protein complexes (CORUM database) featuring SHMT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SHMT2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0042645 mitochondrial nucleoid Database 0.61
Category members GO Category GO:0005759 mitochondrial matrix Database 0.59
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0006544 glycine metabolic process Database 0.35
Category members GO Category GO:0005758 mitochondrial intermembrane space Database 0.33
Category members GO Category GO:0006564 L-serine biosynthetic process Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0005743 mitochondrial inner membrane Database 0.15
Category members Pathway Pathway_275 KEGG_ONE_CARBON_POOL_BY_FOLATE 0 0.11
Category members GO Category GO:0016597 amino acid binding Database 0.11
Category members Pathway Pathway_20 KEGG_GLYCINE_SERINE_AND_THREONINE_METABOLISM 0 0
Category members GO Category GO:0004372 glycine hydroxymethyltransferase activity Database 0
Category members GO Category GO:0006545 glycine biosynthetic process Database 0
Category members GO Category GO:0006563 L-serine metabolic process Database 0
Category members GO Category GO:0006730 one-carbon metabolic process Database 0
Category members GO Category GO:0008168 methyltransferase activity Database 0
Category members GO Category GO:0008284 positive regulation of cell proliferation Database 0
Category members GO Category GO:0008732 L-allo-threonine aldolase activity Database 0
Category members GO Category GO:0019264 glycine biosynthetic process from serine Database 0
Category members GO Category GO:0030170 pyridoxal phosphate binding Database 0
Category members GO Category GO:0035999 tetrahydrofolate interconversion Database 0


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