bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: SETDB1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SETDB1 0 -4.759 0.110 0.270

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SETDB1 Phosphorylation S1066 -0.816 -0.946 _NYGYNPS(ph)PVKPEGLR_
SETDB1 Ubiquitylation K597 -3.267 _GK(gl)NPLLVPLLYDFR_

Background Information for SETDB1:


Pubmed-SETDB1 »
Uniprot-SETDB1 »
Biogrid-SETDB1 »
ProteomicsDB-SETDB1 »

Tumorportal-SETDB1 »
COSMIC-SETDB1 »
GenomeRNAi-SETDB1 »
Genecards-SETDB1


Protein-protein Interactions for SETDB1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SARS Cat. description Hein, Mann, Cell 2015
Category members IP bait SETDB1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC53 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CLPB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAGEA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHKG2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SETDB1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SUV39H1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VHL Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SETDB1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SET_dom IPR001214 0.29
Category members Tudor IPR002999 0.28
Category members Post-SET_dom IPR003616 0.03
Category members Methyl_CpG_DNA-bd IPR001739 0
Category members Pre-SET_Zn-bd_sub IPR003606 0
Category members Pre-SET_dom IPR007728 0
Category members DNA-bd_dom IPR016177 0


Protein complexes (CORUM database) featuring SETDB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2233 Replication-coupled CAF-1-MBD1-ETDB1 complex Database 0
Category members Corum 2238 MBD1-MCAF1-SETDB1 complex Database 0
Category members Corum 2749 SETDB1-containing HMTase complex Database 0


Categories featuring SETDB1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0034968 histone lysine methylation Database 1.1
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_22 KEGG_LYSINE_DEGRADATION 0 0.8
Category members GO Category GO:0018024 histone-lysine N-methyltransferase activity Database 0.73
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members Pathway Pathway_417 PID_WNT_NONCANONICAL_PATHWAY 0 0.09
Category members GO Category GO:0001833 inner cell mass cell proliferation Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0060348 bone development Database 0


.

© Copyright Svejstrup Laboratory 2015