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Query: SBDS

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
SBDS 0 -1.029 0.910 -0.950 -0.390 -0.228 0.247

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
SBDS Phosphorylation T5 -1.684 _(ac)SIFT(ph)PTNQIR_
SBDS Ubiquitylation K35 0.900 _RFEIACYKNK(gl)_
SBDS Ubiquitylation K90 0.641 _QILTK(gl)GEVQVSDKER_
SBDS Ubiquitylation K118 -0.751 _DIATIVADK(gl)CVNPETK_
SBDS Ubiquitylation K138 1.026 _AMK(gl)DIHYSVK_
SBDS Ubiquitylation K151 0.552 _STK(gl)QQALEVIK_
SBDS Ubiquitylation K159 0.900 _QQALEVIK(gl)QLK_
SBDS Ubiquitylation K226 1.011 _EIDELIKK(gl)_

Background Information for SBDS:


Pubmed-SBDS »
Uniprot-SBDS »
Biogrid-SBDS »
ProteomicsDB-SBDS »

Tumorportal-SBDS »
COSMIC-SBDS »
GenomeRNAi-SBDS »
Genecards-SBDS


Protein-protein Interactions for SBDS
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CHAF1A Cat. description Hein, Mann, Cell 2015
Category members IP bait CAV3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CYP1A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FGB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GTF2E2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait INTU Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP27 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in SBDS
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring SBDS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring SBDS
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0006364 rRNA processing Database 2.47
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0042273 ribosomal large subunit biogenesis Database 0.59
Category members GO Category GO:0019843 rRNA binding Database 0.46
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0043022 ribosome binding Database 0.33
Category members GO Category GO:0042256 mature ribosome assembly Database 0.3
Category members GO Category GO:0043148 mitotic spindle stabilization Database 0.29
Category members GO Category GO:0042254 ribosome biogenesis Database 0.29
Category members GO Category GO:0030595 leukocyte chemotaxis Database 0.17
Category members GO Category GO:0008283 cell proliferation Database 0.06
Category members GO Category GO:0030282 bone mineralization Database 0.06
Category members Disease phenotype Idiopathic_aplastic_anemia Idiopathic aplastic anemia Database 0
Category members GO Category GO:0001833 inner cell mass cell proliferation Database 0
Category members GO Category GO:0048539 bone marrow development Database 0


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