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Query: RPN1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
RPN1 0 1.835 0.940 0.740 0.262 0.018 -0.781 0.557 0.400

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
RPN1 Ubiquitylation K553 -0.570 0.943 _VSEMQK(gl)LDAQVK_
RPN1 Ubiquitylation K517 0.437 0.831 _DISTLNSGKK(gl)_
RPN1 Ubiquitylation K538 0.059 0.574 _LK(gl)TEGSDLCDRVSEMQK_
RPN1 Ubiquitylation K187 0.225 0.149 _NVESYTK(gl)LGNPTR_
RPN1 Ubiquitylation K258 -0.934 _HTGAVLK(gl)GPFSR_
RPN1 Ubiquitylation K564 -1.249 _ELVLK(gl)SAVEAER_
RPN1 Ubiquitylation K576 -0.148 _LVAGK(gl)LKK_
RPN1 Ubiquitylation K578 -0.355 _LK(gl)KDTYIENEK_
RPN1 Ubiquitylation K587 -1.128 _DTYIENEK(gl)LISGK_

Background Information for RPN1:


Pubmed-RPN1 »
Uniprot-RPN1 »
Biogrid-RPN1 »
ProteomicsDB-RPN1 »

Tumorportal-RPN1 »
COSMIC-RPN1 »
GenomeRNAi-RPN1 »
Genecards-RPN1


Protein-protein Interactions for RPN1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait SACM1L Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMEM63B Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBA1C Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SCCPDH Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in RPN1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PRTase-like IPR029057 0.32


Protein complexes (CORUM database) featuring RPN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1199 Oligosaccharyltransferase complex (Stt3A variant) Database 0.78
Category members Corum 1200 Oligosaccharyltransferase complex (Stt3B variant) Database 0.78


Categories featuring RPN1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_456 REACTOME_TRANSLATION 0 INF
Category members Pathway Pathway_459 REACTOME_SRP_DEPENDENT_COTRANSLATIONAL_PROTEIN_TARGETING_TO_MEMBRANE 0 INF
Category members GO Category GO:0006412 translation Database INF
Category members GO Category GO:0006614 SRP-dependent cotranslational protein targeting to membrane Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_11 REACTOME_METABOLISM_OF_PROTEINS 0 12.01
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0042470 melanosome Database 5.59
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members Pathway Pathway_467 BIOCARTA_PROTEASOME_PATHWAY 0 0.82
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0004579 dolichyl-diphosphooligosaccharide-protein glycotransferase activity Database 0.38
Category members GO Category GO:0008250 oligosaccharyltransferase complex Database 0.33
Category members GO Category GO:0006486 protein glycosylation Database 0.21
Category members Pathway Pathway_109 KEGG_N_GLYCAN_BIOSYNTHESIS 0 0.04
Category members Pathway Pathway_94 REACTOME_POST_TRANSLATIONAL_PROTEIN_MODIFICATION 0 0
Category members Pathway Pathway_95 REACTOME_ASPARAGINE_N_LINKED_GLYCOSYLATION 0 0
Category members GO Category GO:0005791 rough endoplasmic reticulum Database 0
Category members GO Category GO:0006464 cellular protein modification process Database 0
Category members GO Category GO:0018279 protein N-linked glycosylation via asparagine Database 0
Category members GO Category GO:0043687 post-translational protein modification Database 0


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