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Query: PTPN12

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PTPN12 0 -1.823 -0.330 -0.270

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PTPN12 Phosphorylation S673 -0.767 -0.786 _DVDVSEDS(ph)PPPLPER_
PTPN12 Phosphorylation S571 -1.186 -0.973 _TVSLTPS(ph)PTTQVETPDLVDHDNTSPLFR_
PTPN12 Phosphorylation S588 -1.129 -1.279 _TVSLTPSPTTQVETPDLVDHDNTS(ph)PLFR_

Background Information for PTPN12:


Pubmed-PTPN12 »
Uniprot-PTPN12 »
Biogrid-PTPN12 »
ProteomicsDB-PTPN12 »

Tumorportal-PTPN12 »
COSMIC-PTPN12 »
GenomeRNAi-PTPN12 »
Genecards-PTPN12


Protein-protein Interactions for PTPN12
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait LPXN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPN12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPN6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VAPA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PTPN12
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Tyr_Pase_rcpt/non-rcpt IPR000242 0
Category members Tyr/Dual-sp_Pase IPR000387 0
Category members Tyr_Pase_cat IPR003595 0
Category members Prot-tyrosine_phosphatase-like IPR029021 0


Protein complexes (CORUM database) featuring PTPN12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PTPN12
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0002102 podosome Database 0.3
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members GO Category GO:0004725 protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0004726 non-membrane spanning protein tyrosine phosphatase activity Database 0
Category members GO Category GO:0006470 protein dephosphorylation Database 0
Category members GO Category GO:0016311 dephosphorylation Database 0
Category members GO Category GO:0016791 phosphatase activity Database 0
Category members GO Category GO:0017124 SH3 domain binding Database 0
Category members GO Category GO:0030054 cell junction Database 0
Category members GO Category GO:0042995 cell projection Database 0


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