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Query: PSMC6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PSMC6 0 1.437 1.170 -0.580 -0.025 0.192

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PSMC6 Ubiquitylation K20 -0.044 0.744 _LLEHK(gl)EIDGR_
PSMC6 Ubiquitylation K7 0.253 0.732 _DK(gl)ALQDYR_
PSMC6 Ubiquitylation K383 0.276 -0.218 _KLESK(gl)LDYKPV_
PSMC6 Ubiquitylation K34 -0.419 _EQLK(gl)ELTK_
PSMC6 Ubiquitylation K197 0.526 _AVASQLDCNFLK(gl)_

Background Information for PSMC6:


Pubmed-PSMC6 »
Uniprot-PSMC6 »
Biogrid-PSMC6 »
ProteomicsDB-PSMC6 »

Tumorportal-PSMC6 »
COSMIC-PSMC6 »
GenomeRNAi-PSMC6 »
Genecards-PSMC6


Protein-protein Interactions for PSMC6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait GNPNAT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMB4 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMB5 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMD14 Cat. description Hein, Mann, Cell 2015
Category members IP bait PSMD6 Cat. description Hein, Mann, Cell 2015
Category members IP bait ADRM1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC74B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC92 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMB3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMB9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMC5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMD12 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMD5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PSMD9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UCHL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZFAND2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PSMC6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members ATPase_dyneun-rel_AAA IPR011704 2.54
Category members DNA_helicase_Holl-junc_RuvB_N IPR008824 1.05
Category members 26S_Psome_P45 IPR005937 0.44
Category members AAA+_ATPase IPR003593 0.38
Category members ATPase_AAA_core IPR003959 0.14


Protein complexes (CORUM database) featuring PSMC6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 32 PA700 complex Database 1.8
Category members Corum 193 PA700-20S-PA28 complex Database 0.98
Category members Corum 181 26S proteasome Database 0.37


Categories featuring PSMC6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_771 REACTOME_METABOLISM_OF_RNA 0 INF
Category members Pathway Pathway_773 REACTOME_METABOLISM_OF_MRNA 0 INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0006281 DNA repair Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0016032 viral process Database INF
Category members GO Category GO:0016070 RNA metabolic process Database INF
Category members GO Category GO:0016071 mRNA metabolic process Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_197 REACTOME_HIV_INFECTION 0 12.07
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members Pathway Pathway_196 REACTOME_HOST_INTERACTIONS_OF_HIV_FACTORS 0 9.67
Category members GO Category GO:0000166 nucleotide binding Database 5.91
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_321 REACTOME_MITOTIC_M_M_G1_PHASES 0 5.47
Category members Pathway Pathway_323 REACTOME_DNA_REPLICATION 0 5.24
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_790 REACTOME_CELL_CYCLE_CHECKPOINTS 0 3.89
Category members GO Category GO:0006511 ubiquitin-dependent protein catabolic process Database 3.57
Category members GO Category GO:0051437 positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.38
Category members GO Category GO:0051436 negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.35
Category members GO Category GO:0051439 regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle Database 3.26
Category members GO Category GO:0000502 proteasome complex Database 3.17
Category members GO Category GO:0006310 DNA recombination Database 3.14
Category members Pathway Pathway_827 REACTOME_AUTODEGRADATION_OF_CDH1_BY_CDH1_APC_C 0 3.01
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members Pathway Pathway_765 REACTOME_ER_PHAGOSOME_PATHWAY 0 2.74
Category members Pathway Pathway_807 REACTOME_SIGNALING_BY_WNT 0 2.74
Category members GO Category GO:0031145 anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process Database 2.59
Category members Pathway Pathway_764 REACTOME_CLASS_I_MHC_MEDIATED_ANTIGEN_PROCESSING_PRESENTATION 0 2.56
Category members GO Category GO:0002474 antigen processing and presentation of peptide antigen via MHC class I Database 2.5
Category members Pathway Pathway_780 REACTOME_APC_C_CDH1_MEDIATED_DEGRADATION_OF_CDC20_AND_OTHER_APC_C_CDH1_TARGETED_PROTEINS_IN_LATE_MITOSIS_EARLY_G1 0 2.46
Category members GO Category GO:0000209 protein polyubiquitination Database 2.46
Category members GO Category GO:0002479 antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent Database 2.46
Category members Pathway Pathway_837 REACTOME_APOPTOSIS 0 2.39
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members Pathway Pathway_784 REACTOME_APC_C_CDC20_MEDIATED_DEGRADATION_OF_MITOTIC_PROTEINS 0 2.26
Category members Pathway Pathway_763 REACTOME_ANTIGEN_PROCESSING_CROSS_PRESENTATION 0 2.24
Category members GO Category GO:0042590 antigen processing and presentation of exogenous peptide antigen via MHC class I Database 2.21
Category members Pathway Pathway_315 REACTOME_S_PHASE 0 2.19
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members Pathway Pathway_660 REACTOME_SIGNALING_BY_THE_B_CELL_RECEPTOR_BCR 0 2.12
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members Pathway Pathway_781 REACTOME_REGULATION_OF_MRNA_STABILITY_BY_PROTEINS_THAT_BIND_AU_RICH_ELEMENTS 0 2.04
Category members Pathway Pathway_330 REACTOME_SYNTHESIS_OF_DNA 0 1.96
Category members Pathway Pathway_706 REACTOME_DOWNSTREAM_SIGNALING_EVENTS_OF_B_CELL_RECEPTOR_BCR 0 1.96
Category members Pathway Pathway_788 REACTOME_REGULATION_OF_MITOTIC_CELL_CYCLE 0 1.91
Category members Pathway Pathway_322 REACTOME_G1_S_TRANSITION 0 1.77
Category members Pathway Pathway_820 REACTOME_ORC1_REMOVAL_FROM_CHROMATIN 0 1.75
Category members Pathway Pathway_798 REACTOME_P53_INDEPENDENT_G1_S_DNA_DAMAGE_CHECKPOINT 0 1.64
Category members Pathway Pathway_787 REACTOME_ASSEMBLY_OF_THE_PRE_REPLICATIVE_COMPLEX 0 1.59
Category members Pathway Pathway_832 REACTOME_ANTIGEN_PROCESSING_UBIQUITINATION_PROTEASOME_DEGRADATION 0 1.58
Category members Pathway Pathway_313 REACTOME_MITOTIC_G1_G1_S_PHASES 0 1.45
Category members Pathway Pathway_776 REACTOME_DESTABILIZATION_OF_MRNA_BY_AUF1_HNRNP_D0 0 1.45
Category members Pathway Pathway_331 REACTOME_M_G1_TRANSITION 0 1.43
Category members GO Category GO:0006977 DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Database 1.39
Category members GO Category GO:0022624 proteasome accessory complex Database 1.36
Category members Pathway Pathway_900 KEGG_PROTEASOME 0 1.34
Category members Pathway Pathway_817 REACTOME_CDK_MEDIATED_PHOSPHORYLATION_AND_REMOVAL_OF_CDC6 0 1.24
Category members GO Category GO:0000082 G1/S transition of mitotic cell cycle Database 1.23
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_796 REACTOME_VIF_MEDIATED_DEGRADATION_OF_APOBEC3G 0 1.14
Category members Pathway Pathway_811 REACTOME_SCF_BETA_TRCP_MEDIATED_DEGRADATION_OF_EMI1 0 1.14
Category members Pathway Pathway_801 REACTOME_AUTODEGRADATION_OF_THE_E3_UBIQUITIN_LIGASE_COP1 0 1.09
Category members GO Category GO:0009378 four-way junction helicase activity Database 1.06
Category members Pathway Pathway_910 REACTOME_CROSS_PRESENTATION_OF_SOLUBLE_EXOGENOUS_ANTIGENS_ENDOSOMES 0 1.03
Category members Pathway Pathway_830 REACTOME_P53_DEPENDENT_G1_DNA_DAMAGE_RESPONSE 0 0.93
Category members Pathway Pathway_804 REACTOME_ACTIVATION_OF_NF_KAPPAB_IN_B_CELLS 0 0.86
Category members Pathway Pathway_467 BIOCARTA_PROTEASOME_PATHWAY 0 0.82
Category members Pathway Pathway_828 REACTOME_CDT1_ASSOCIATION_WITH_THE_CDC6_ORC_ORIGIN_COMPLEX 0 0.82
Category members GO Category GO:0042981 regulation of apoptotic process Database 0.79
Category members Pathway Pathway_782 REACTOME_SCFSKP2_MEDIATED_DEGRADATION_OF_P27_P21 0 0.66
Category members Pathway Pathway_835 REACTOME_CYCLIN_E_ASSOCIATED_EVENTS_DURING_G1_S_TRANSITION_ 0 0.63
Category members GO Category GO:0006521 regulation of cellular amino acid metabolic process Database 0.62
Category members GO Category GO:0043066 negative regulation of apoptotic process Database 0.6
Category members GO Category GO:0017111 nucleoside-triphosphatase activity Database 0.5
Category members Pathway Pathway_441 REACTOME_REGULATION_OF_ORNITHINE_DECARBOXYLASE_ODC 0 0.45
Category members GO Category GO:0030163 protein catabolic process Database 0.38
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_795 REACTOME_REGULATION_OF_APOPTOSIS 0 0.31
Category members GO Category GO:0030674 protein binding, bridging Database 0.25
Category members GO Category GO:0031597 cytosolic proteasome complex Database 0.23
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0016234 inclusion body Database 0.14
Category members GO Category GO:0034641 cellular nitrogen compound metabolic process Database 0.01
Category members Pathway Pathway_17 REACTOME_METABOLISM_OF_AMINO_ACIDS_AND_DERIVATIVES 0 0


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