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Query: PRPF8

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PRPF8 2 8.645 0.601 -0.444 0.045 -0.568 -0.007

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PRPF8 Ubiquitylation K847 4.280 4.737 _LK(gl)EAYSVK_
PRPF8 Ubiquitylation K449 0.961 _VSYQK(gl)LLK_
PRPF8 Ubiquitylation K853 0.313 0.906 _EAYSVK(gl)SR_
PRPF8 Ubiquitylation K218 0.783 _K(gl)YVNGSTYQR_
PRPF8 Ubiquitylation K2034 0.488 0.601 _QTK(gl)EQSQLTATQTR_
PRPF8 Ubiquitylation K1158 0.553 _AVFWDIK(gl)NR_
PRPF8 Ubiquitylation K785 1.193 0.381 _LYLK(gl)AEQER_
PRPF8 Ubiquitylation K1392 0.488 0.214 _VWAEYALK(gl)R_
PRPF8 Ubiquitylation K1443 0.849 0.161 _TDFK(gl)QYQVLK_
PRPF8 Ubiquitylation K1144 1.075 0.092 _LMK(gl)HDVNLGR_
PRPF8 Ubiquitylation K1735 0.067 _IMK(gl)ANPALYVLR_
PRPF8 Ubiquitylation K442 -0.412 -0.328 _EHCPAGQPVK(gl)VR_
PRPF8 Ubiquitylation K1993 0.886 -0.521 _DLILADYGK(gl)K_
PRPF8 Ubiquitylation K1994 0.886 -0.521 _DLILADYGK(gl)K_
PRPF8 Ubiquitylation K1131 -0.581 _YLTEHPDPNNENIVGYNNK(gl)K_
PRPF8 Ubiquitylation K1132 -0.621 _YLTEHPDPNNENIVGYNNKK(gl)_
PRPF8 Ubiquitylation K1859 -0.720 _SLPVEEQPK(gl)QIIVTR_
PRPF8 Ubiquitylation K2140 -0.848 _AQIAGYLYGVSPPDNPQVK(gl)EIR_
PRPF8 Ubiquitylation K36 1.198 _K(gl)WQQLQAK_
PRPF8 Ubiquitylation K1300 1.721 _IK(gl)IGLNSK_
PRPF8 Ubiquitylation K1344 0.647 _WSK(gl)QTDVGITHFR_
PRPF8 Ubiquitylation K2031 0.976 _QQIAEIEK(gl)QTK_

Background Information for PRPF8:


Pubmed-PRPF8 »
Uniprot-PRPF8 »
Biogrid-PRPF8 »
ProteomicsDB-PRPF8 »

Tumorportal-PRPF8 »
COSMIC-PRPF8 »
GenomeRNAi-PRPF8 »
Genecards-PRPF8


Protein-protein Interactions for PRPF8
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BCAS2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC12 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUP Cat. description Hein, Mann, Cell 2015
Category members IP bait PQBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PRPF4 Cat. description Hein, Mann, Cell 2015
Category members IP bait SART1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SCARB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SNW1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WBP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait BSG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C20orf4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C2orf3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CD2BP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DDX23 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait EAPP Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ECD Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KIAA1143 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRNP40 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPE Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPF Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPG Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNRPN Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TSSC4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PRPF8
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members JAMM/MPN+_dom IPR000555 1.33
Category members Histone-fold IPR009072 0.01
Category members Cupredoxin IPR008972 0


Protein complexes (CORUM database) featuring PRPF8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 351 Spliceosome Database 9.3
Category members Corum 1335 SNW1 complex Database 3.59
Category members Corum 1181 C complex spliceosome Database 2.39
Category members Corum 924 Toposome Database 0.88
Category members Corum 430 18S U11/U12 snRNP Database 0.29
Category members Corum 1195 Exon junction complex (mRNA splicing-dependent) Database 0


Categories featuring PRPF8
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0003723 RNA binding Database INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members DDR Literature pubmedid:TBD1_UV_decreased Elia et al, 2015 UV decreased acetylation events Elia et al. 10.54
Category members Pathway Pathway_851 KEGG_SPLICEOSOME 0 7.94
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0005681 spliceosomal complex Database 3.88
Category members GO Category GO:0006397 mRNA processing Database 3.76
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0071013 catalytic step 2 spliceosome Database 2.28
Category members Pathway Pathway_372 REACTOME_MRNA_SPLICING_MINOR_PATHWAY 0 1.52
Category members GO Category GO:0000375 RNA splicing, via transesterification reactions Database 0.73
Category members GO Category GO:0005682 U5 snRNP Database 0.57
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Disease phenotype Retinitis_pigmentosa Retinitis pigmentosa Database 0
Category members GO Category GO:0017070 U6 snRNA binding Database 0


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