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Query: PPP4C

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PPP4C 0 0.227 -0.050 0.050 0.322

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PPP4C Ubiquitylation K31 -0.607 0.349 _ESEVK(gl)ALCAK(gl)AR_
PPP4C Ubiquitylation K26 -0.494 -0.192 _ESEVK(gl)ALCAK(gl)AR_
PPP4C Ubiquitylation K133 -0.603 _K(gl)YGSVTVWR_

Background Information for PPP4C:


Pubmed-PPP4C »
Uniprot-PPP4C »
Biogrid-PPP4C »
ProteomicsDB-PPP4C »

Tumorportal-PPP4C »
COSMIC-PPP4C »
GenomeRNAi-PPP4C »
Genecards-PPP4C


Protein-protein Interactions for PPP4C
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait IGBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CA Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2CB Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4C Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4R1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP4R2 Cat. description Hein, Mann, Cell 2015
Category members IP bait SMEK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LCMT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP2R2D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP4R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP4R4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SMEK1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PPP4C
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Ser/Thr-sp_prot-phosphatase IPR006186 0.88
Category members Calcineurin-like_PHP_apaH IPR004843 0.24
Category members Metallo-depent_PP-like IPR029052 0.23


Protein complexes (CORUM database) featuring PPP4C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1245 Protein phosphatase 4 complex Database 0
Category members Corum 1750 PPP4C-PPP4R2-Gemin3-Gemin4 complex Database 0


Categories featuring PPP4C
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0000226 microtubule cytoskeleton organization Database 0.5
Category members GO Category GO:0016787 hydrolase activity Database 0.22
Category members GO Category GO:0004722 protein serine/threonine phosphatase activity Database 0.11
Category members GO Category GO:0004721 phosphoprotein phosphatase activity Database 0.11
Category members GO Category GO:0004704 NF-kappaB-inducing kinase activity Database 0.05
Category members GO Category GO:0010569 regulation of double-strand break repair via homologous recombination Database 0.01
Category members GO Category GO:0030289 protein phosphatase 4 complex Database 0
Category members GO Category GO:0038061 NIK/NF-kappaB signaling Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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