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Query: POLR3B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLR3B 0 3.167 0.540 -0.900 1.056 0.594

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLR3B Ubiquitylation K968 0.649 0.285 _FHYGTAFGGSK(gl)VK_
POLR3B Ubiquitylation K404 1.232 _AAQFDVVK(gl)HMR_

Background Information for POLR3B:


Pubmed-POLR3B »
Uniprot-POLR3B »
Biogrid-POLR3B »
ProteomicsDB-POLR3B »

Tumorportal-POLR3B »
COSMIC-POLR3B »
GenomeRNAi-POLR3B »
Genecards-POLR3B


Protein-protein Interactions for POLR3B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ACTR1B Cat. description Hein, Mann, Cell 2015
Category members IP bait C20orf172;DSN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait GSK3A Cat. description Hein, Mann, Cell 2015
Category members IP bait MATR3 Cat. description Hein, Mann, Cell 2015
Category members IP bait NAA11 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2F Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR3E Cat. description Hein, Mann, Cell 2015
Category members IP bait RUVBL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait APOBEC3D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PIH1D1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR1C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR2E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR3D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR3E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR3GL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPP1CC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UXT Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLR3B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DNA-dir_RNA_pol_su2_6 IPR007120 0.68
Category members RNA_pol_Rpb2_7 IPR007641 0.68
Category members RNA_pol_Rpb2_2 IPR007642 0.68
Category members RNA_pol_bsu_protrusion IPR007644 0.68
Category members RNA_pol_Rpb2_3 IPR007645 0.68
Category members RNA_pol_Rpb2_5 IPR007647 0.68
Category members RNA_pol_Rpb2_4 IPR007646 0.28


Protein complexes (CORUM database) featuring POLR3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring POLR3B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0032549 ribonucleoside binding Database 1.21
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0001056 RNA polymerase III activity Database 1.02
Category members Pathway Pathway_349 KEGG_RNA_POLYMERASE 0 0.91
Category members GO Category GO:0032481 positive regulation of type I interferon production Database 0.54
Category members GO Category GO:0003899 DNA-directed RNA polymerase activity Database 0.46
Category members Pathway Pathway_355 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_2_PROMOTER 0 0.37
Category members Pathway Pathway_353 REACTOME_RNA_POL_III_TRANSCRIPTION_TERMINATION 0 0.29
Category members Pathway Pathway_357 REACTOME_RNA_POL_III_TRANSCRIPTION 0 0.29
Category members GO Category GO:0005666 DNA-directed RNA polymerase III complex Database 0.29
Category members Disease phenotype Hypomyelination_-_hypogonadotropic_hypogonadism_-_hypodontia Hypomyelination - hypogonadotropic hypogonadism - hypodontia Database 0.28
Category members Pathway Pathway_356 REACTOME_RNA_POL_III_CHAIN_ELONGATION 0 0.23
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0006383 transcription from RNA polymerase III promoter Database 0.18
Category members GO Category GO:0006385 transcription elongation from RNA polymerase III promoter Database 0.18
Category members GO Category GO:0006386 termination of RNA polymerase III transcription Database 0.18
Category members Pathway Pathway_352 REACTOME_RNA_POL_III_TRANSCRIPTION_INITIATION_FROM_TYPE_3_PROMOTER 0 0.11
Category members GO Category GO:0051607 defense response to virus Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0045089 positive regulation of innate immune response Database 0.05
Category members Pathway Pathway_354 KEGG_CYTOSOLIC_DNA_SENSING_PATHWAY 0 0
Category members Disease phenotype Autosomal_Recessive_Mental_Retardation Autosomal Recessive Mental Retardation Database 0
Category members GO Category GO:0032728 positive regulation of interferon-beta production Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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