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Query: POLR1B

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLR1B 1 6.497 -1.220 2.660 0.614 0.697 0.425 1.045 0.207

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLR1B Ubiquitylation K882 0.509 0.340 _SK(gl)ENCVVDNIK_
POLR1B Ubiquitylation K70 -0.356 _EQQK(gl)AALQELTR_
POLR1B Ubiquitylation K132 -0.885 _GTICK(gl)EANVYPAECR_
POLR1B Ubiquitylation K518 -1.235 _GADFAK(gl)MR_

Background Information for POLR1B:


Pubmed-POLR1B »
Uniprot-POLR1B »
Biogrid-POLR1B »
ProteomicsDB-POLR1B »

Tumorportal-POLR1B »
COSMIC-POLR1B »
GenomeRNAi-POLR1B »
Genecards-POLR1B


Protein-protein Interactions for POLR1B
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ERBB2 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR1A Cat. description Hein, Mann, Cell 2015
Category members IP bait POLR2F Cat. description Hein, Mann, Cell 2015
Category members IP bait GPN3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LOC554223 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR1C Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait POLR2E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TWISTNB Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLR1B
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members DNA-dir_RNA_pol_su2_6 IPR007120 0.68
Category members RNA_pol_Rpb2_7 IPR007641 0.68
Category members RNA_pol_Rpb2_2 IPR007642 0.68
Category members RNA_pol_bsu_protrusion IPR007644 0.68
Category members RNA_pol_Rpb2_3 IPR007645 0.68
Category members RNA_pol_Rpb2_5 IPR007647 0.68


Protein complexes (CORUM database) featuring POLR1B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5233 TNF-alpha/NF-kappa B signaling complex 5 Database 0.29
Category members Corum 1558 POLR1B-RRN3 complex Database 0.29
Category members Corum 1557 NMI-POLR1B-RRN3 complex Database 0.08


Categories featuring POLR1B
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members Pathway Pathway_351 REACTOME_RNA_POL_I_TRANSCRIPTION 0 8.31
Category members Pathway Pathway_350 REACTOME_RNA_POL_I_RNA_POL_III_AND_MITOCHONDRIAL_TRANSCRIPTION 0 7.97
Category members Pathway Pathway_346 REACTOME_RNA_POL_I_TRANSCRIPTION_INITIATION 0 3.42
Category members GO Category GO:0006360 transcription from RNA polymerase I promoter Database 2.66
Category members GO Category GO:0006361 transcription initiation from RNA polymerase I promoter Database 2.41
Category members Pathway Pathway_345 REACTOME_RNA_POL_I_TRANSCRIPTION_TERMINATION 0 1.9
Category members GO Category GO:0006363 termination of RNA polymerase I transcription Database 1.71
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006362 transcription elongation from RNA polymerase I promoter Database 1.47
Category members GO Category GO:0032549 ribonucleoside binding Database 1.21
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0001054 RNA polymerase I activity Database 1.02
Category members Pathway Pathway_349 KEGG_RNA_POLYMERASE 0 0.91
Category members GO Category GO:0005736 DNA-directed RNA polymerase I complex Database 0.78
Category members GO Category GO:0003899 DNA-directed RNA polymerase activity Database 0.46
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members Pathway Pathway_347 BIOCARTA_ARF_PATHWAY 0 0.12
Category members GO Category GO:0007566 embryo implantation Database 0
Category members GO Category GO:0009303 rRNA transcription Database 0
Category members GO Category GO:0009790 embryo development Database 0
Category members GO Category GO:0046872 metal ion binding Database 0


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