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Query: POLE3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
POLE3 0 -1.767 -0.830 0.170 -0.901 -0.263

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
POLE3 Ubiquitylation K31 -0.408 -0.365 _EALPDGVNISK(gl)EAR_

Background Information for POLE3:


Pubmed-POLE3 »
Uniprot-POLE3 »
Biogrid-POLE3 »
ProteomicsDB-POLE3 »

Tumorportal-POLE3 »
COSMIC-POLE3 »
GenomeRNAi-POLE3 »
Genecards-POLE3


Protein-protein Interactions for POLE3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIF21B Cat. description Hein, Mann, Cell 2015
Category members IP bait ORC1 Cat. description Hein, Mann, Cell 2015
Category members IP bait YEATS4 Cat. description Hein, Mann, Cell 2015
Category members IP bait POLE2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in POLE3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Histone-fold IPR009072 0.01
Category members CBFA_NFYB_domain IPR003958 0


Protein complexes (CORUM database) featuring POLE3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1099 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 1111 DNA synthesome complex (17 subunits) Database 0.22
Category members Corum 234 HuCHRAC complex Database 0.02
Category members Corum 1108 DNA synthesome complex (15 subunits) Database 0


Categories featuring POLE3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members Pathway Pathway_339 KEGG_NUCLEOTIDE_EXCISION_REPAIR 0 4.91
Category members GO Category GO:0006260 DNA replication Database 3.34
Category members Pathway Pathway_329 KEGG_DNA_REPLICATION 0 0.95
Category members GO Category GO:0005622 intracellular Database 0.32
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members Pathway Pathway_68 KEGG_PURINE_METABOLISM 0 0.23
Category members Pathway Pathway_277 KEGG_PYRIMIDINE_METABOLISM 0 0.18
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members Pathway Pathway_334 KEGG_BASE_EXCISION_REPAIR 0 0
Category members GO Category GO:0003887 DNA-directed DNA polymerase activity Database 0
Category members GO Category GO:0005671 Ada2/Gcn5/Ada3 transcription activator complex Database 0
Category members GO Category GO:0008622 epsilon DNA polymerase complex Database 0
Category members GO Category GO:0043966 histone H3 acetylation Database 0


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