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Query: PKN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PKN2 0 3.649 0.530 -0.200 -0.561 -0.138 0.314

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PKN2 Phosphorylation S583 0.827 1.023 _ASS(ph)LGEIDESSELR_
PKN2 Phosphorylation S582 0.725 0.956 _AS(ph)SLGEIDESSELR_
PKN2 Ubiquitylation K447 0.735 _SLCAVK(gl)FLR_
PKN2 Phosphorylation S110 -0.178 0.111 _LQELNAHIVVS(ph)DPEDITDCPR_
PKN2 Phosphorylation S360 -0.306 -0.065 _ATSVALPGWS(ph)PSETR_
PKN2 Phosphorylation T958 -1.135 -0.827 _GREDVSNFDDEFTSEAPILT(ph)PPREPR_
PKN2 Phosphorylation T527 -1.598 -1.740 _AIPT(ph)VNHSGTFSPQAPVPTTVPVVDVR_
PKN2 Phosphorylation S535 -1.794 _AIPTVNHSGTFS(ph)PQAPVPTTVPVVDVR_
PKN2 Ubiquitylation K385 0.967 _NLLK(gl)TDDLSNDVCAVLK_
PKN2 Ubiquitylation K502 1.448 _QQGK(gl)TFLR_
PKN2 Ubiquitylation K930 -0.445 _VK(gl)PPFIPTIR_

Background Information for PKN2:


Pubmed-PKN2 »
Uniprot-PKN2 »
Biogrid-PKN2 »
ProteomicsDB-PKN2 »

Tumorportal-PKN2 »
COSMIC-PKN2 »
GenomeRNAi-PKN2 »
Genecards-PKN2


Protein-protein Interactions for PKN2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait PKN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RUFY1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAMKV Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CETN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DEF8 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DFFB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FRMPD2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GOPC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HAVCR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PPIAL4G Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RHOA Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TGFBR2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF785 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PKN2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members HR1_rho-bd IPR011072 0.07
Category members Kinase-like_dom IPR011009 0.03
Category members C2_dom IPR000008 0
Category members Prot_kinase_dom IPR000719 0
Category members AGC-kinase_C IPR000961 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Pkinase_C IPR017892 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring PKN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PKN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members GO Category GO:0030027 lamellipodium Database 1.77
Category members GO Category GO:0051301 cell division Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0007049 cell cycle Database 0.69
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0032467 positive regulation of cytokinesis Database 0.35
Category members GO Category GO:0043297 apical junction assembly Database 0.28
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0043296 apical junction complex Database 0.18
Category members GO Category GO:0042826 histone deacetylase binding Database 0.16
Category members GO Category GO:0010631 epithelial cell migration Database 0.15
Category members GO Category GO:0004697 protein kinase C activity Database 0.09
Category members GO Category GO:0045931 positive regulation of mitotic cell cycle Database 0.04
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Pathway Pathway_668 PID_RHOA_PATHWAY 0 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007155 cell adhesion Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0


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