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Query: PIK3C3

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PIK3C3 0 -0.220 -0.260 0.520

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PIK3C3 Ubiquitylation K29 0.271 _IGSLEGK(gl)R_
PIK3C3 Ubiquitylation K287 -1.261 _SGPSDHDLK(gl)PNAATR_
PIK3C3 Ubiquitylation K158 -1.333 _VWPNVEADGSEPTK(gl)TPGR_
PIK3C3 Ubiquitylation K209 -1.012 _EIEMINESEK(gl)R_

Background Information for PIK3C3:


Pubmed-PIK3C3 »
Uniprot-PIK3C3 »
Biogrid-PIK3C3 »
ProteomicsDB-PIK3C3 »

Tumorportal-PIK3C3 »
COSMIC-PIK3C3 »
GenomeRNAi-PIK3C3 »
Genecards-PIK3C3


Protein-protein Interactions for PIK3C3
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BECN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait ATG14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C13orf18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGALS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NRBF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF15 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SKAP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PIK3C3
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members ARM-type_fold IPR016024 9.26
Category members PI3/4_kinase_cat_dom IPR000403 1.52
Category members PInositide-3_kin_accessory_dom IPR001263 0.13
Category members PI3K_C2_dom IPR002420 0.04
Category members Kinase-like_dom IPR011009 0.03
Category members C2_dom IPR000008 0


Protein complexes (CORUM database) featuring PIK3C3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 429 Phosphatidylinositol 3-kinase complex (PIK3C3, PIK3R4) Database 0


Categories featuring PIK3C3
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005488 binding Database 9.32
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0048015 phosphatidylinositol-mediated signaling Database 0.98
Category members GO Category GO:0016485 protein processing Database 0.57
Category members Pathway Pathway_501 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE 0 0.46
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0046854 phosphatidylinositol phosphorylation Database 0.31
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members Pathway Pathway_106 KEGG_INOSITOL_PHOSPHATE_METABOLISM 0 0.28
Category members GO Category GO:0043201 response to leucine Database 0.26
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0008286 insulin receptor signaling pathway Database 0.2
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members GO Category GO:0007032 endosome organization Database 0.11
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0006661 phosphatidylinositol biosynthetic process Database 0.06
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members Pathway Pathway_103 REACTOME_PI_METABOLISM 0 0.04
Category members GO Category GO:0034162 toll-like receptor 9 signaling pathway Database 0.04
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_104 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_LATE_ENDOSOME_MEMBRANE 0 0
Category members Pathway Pathway_105 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_EARLY_ENDOSOME_MEMBRANE 0 0
Category members Pathway Pathway_190 REACTOME_SIGNALING_BY_INSULIN_RECEPTOR 0 0
Category members Pathway Pathway_303 REACTOME_INSULIN_RECEPTOR_SIGNALLING_CASCADE 0 0
Category members Pathway Pathway_304 REACTOME_PI3K_CASCADE 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members Pathway Pathway_526 KEGG_REGULATION_OF_AUTOPHAGY 0 0
Category members GO Category GO:0000045 autophagic vacuole assembly Database 0
Category members GO Category GO:0005930 axoneme Database 0
Category members GO Category GO:0005942 phosphatidylinositol 3-kinase complex Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0016303 1-phosphatidylinositol-3-kinase activity Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0016773 phosphotransferase activity, alcohol group as acceptor Database 0
Category members GO Category GO:0035004 phosphatidylinositol 3-kinase activity Database 0
Category members GO Category GO:0036092 phosphatidylinositol-3-phosphate biosynthetic process Database 0
Category members GO Category GO:0045022 early endosome to late endosome transport Database 0
Category members GO Category GO:0050708 regulation of protein secretion Database 0


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