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bioLOGIC Data

Query: PIAS2

RNAi screen result	RNAPII IP (PI)	CSB IP	CSB IP (PI)	Chrom.	Chrom. (PI)	Phosphorylation	Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:
Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen

Gene name	Point score	Z-score sums	RNAi high	RNAi low	RNAPII-IP (PI)	CSB-IP	CSB-IP (PI)	Chrom.	Chrom. (PI)
PIAS2	0	-0.942	-0.510	0.250
PIAS2	0	-0.942	-0.510	0.250	-1.034	-0.678	0.471	-0.051	1.019

PTM Sites:
Back to Protein Results | Red/green: hit at lower/upper end of the respective screen

Gene name	PTM type	PTM site	UV	UV (PI)	Sequence
PIAS2	Phosphorylation	S505	0.198	-0.250	_GILSLPHQAS(ph)PVSR_
PIAS2	Ubiquitylation	K331		-0.867	_VSLMCPLGK(gl)MR_
PIAS2	Phosphorylation	S490	-0.898	-0.944	_RTCPSLSPTS(ph)PLNNK_
PIAS2	Ubiquitylation	K452		-1.175	_IESSSVLSK(gl)PCSVTVASEASK_
PIAS2	Ubiquitylation	K60		-1.191	_AGCSPAVQMKIK(gl)_
PIAS2	Ubiquitylation	K341		-1.248	_VSLLCPLGK(gl)MR_

Background Information for PIAS2:

Pubmed-PIAS2 »

Uniprot-PIAS2 »

Biogrid-PIAS2 »

ProteomicsDB-PIAS2 »

Tumorportal-PIAS2 »

COSMIC-PIAS2 »

GenomeRNAi-PIAS2 »

Genecards-PIAS2

Protein-protein Interactions for PIAS2

Show screen data for	Category Name and Description	Link to cat description	Data Source
Category members	IP bait CCT4	Cat. description	Hein, Mann, Cell 2015
Category members	IP bait TUBA3C;TUBA3E	Cat. description	Hein, Mann, Cell 2015

Protein Domains in PIAS2

	Domain name	Domain Description	TC-NER relevance -log10(p-value)
Category members	SAP_dom	IPR003034	1.96
Category members	Znf_MIZ	IPR004181	0.13

Protein complexes (CORUM database) featuring PIAS2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)

Categories featuring PIAS2

	Category Type	Category ID	Category Name	Data Source	TC-NER relevance -log10(p-value)
Category members	GO Category	GO:0005515	protein binding	Database	INF
Category members	GO Category	GO:0005634	nucleus	Database	INF
Category members	GO Category	GO:0016607	nuclear speck	Database	4.84
Category members	GO Category	GO:0003713	transcription coactivator activity	Database	3.68
Category members	GO Category	GO:0031625	ubiquitin protein ligase binding	Database	2.54
Category members	Pathway	Pathway_888	KEGG_UBIQUITIN_MEDIATED_PROTEOLYSIS	0	2.22
Category members	GO Category	GO:0003677	DNA binding	Database	1.53
Category members	GO Category	GO:0016605	PML body	Database	1.41
Category members	Pathway	Pathway_1254	PID_RANBP2_PATHWAY	0	1.33
Category members	GO Category	GO:0030521	androgen receptor signaling pathway	Database	1.25
Category members	GO Category	GO:0006351	transcription, DNA-templated	Database	1.07
Category members	GO Category	GO:0003676	nucleic acid binding	Database	0.83
Category members	GO Category	GO:0060766	negative regulation of androgen receptor signaling pathway	Database	0.35
Category members	GO Category	GO:0016925	protein sumoylation	Database	0.33
Category members	GO Category	GO:0008270	zinc ion binding	Database	0.29
Category members	GO Category	GO:0045893	positive regulation of transcription, DNA-dependent	Database	0.28
Category members	GO Category	GO:0006357	regulation of transcription from RNA polymerase II promoter	Database	0.19
Category members	GO Category	GO:0045944	positive regulation of transcription from RNA polymerase II promoter	Database	0.13
Category members	Pathway	Pathway_447	KEGG_JAK_STAT_SIGNALING_PATHWAY	0	0.13
Category members	GO Category	GO:0050681	androgen receptor binding	Database	0.12
Category members	GO Category	GO:0019789	SUMO ligase activity	Database	0.05
Category members	GO Category	GO:0016604	nuclear body	Database	0.04
Category members	Pathway	Pathway_24	KEGG_PATHWAYS_IN_CANCER	0	0
Category members	Pathway	Pathway_283	KEGG_SMALL_CELL_LUNG_CANCER	0	0
Category members	Pathway	Pathway_904	PID_IL12_STAT4_PATHWAY	0	0
Category members	GO Category	GO:0045667	regulation of osteoblast differentiation	Database	0