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Query: PFKM

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PFKM 0 -1.366 -0.290 -0.020
PFKM 0 -1.366 -0.290 -0.020 -0.313

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PFKM Ubiquitylation K215 -0.787 -0.246 _AGK(gl)ITDEEATK_
PFKM Ubiquitylation K431 -0.696 _DVTK(gl)AMDEK_
PFKM Ubiquitylation K427 -0.699 _LPLMECVQVTK(gl)DVTK_
PFKM Ubiquitylation K178 -0.734 _AAYNLVK(gl)R_

Background Information for PFKM:


Pubmed-PFKM »
Uniprot-PFKM »
Biogrid-PFKM »
ProteomicsDB-PFKM »

Tumorportal-PFKM »
COSMIC-PFKM »
GenomeRNAi-PFKM »
Genecards-PFKM


Protein-protein Interactions for PFKM
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP78 Cat. description Hein, Mann, Cell 2015
Category members IP bait CKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ELMSAN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF11 Cat. description Hein, Mann, Cell 2015
Category members IP bait SESN2 Cat. description Hein, Mann, Cell 2015
Category members IP bait TUBG1 Cat. description Hein, Mann, Cell 2015
Category members IP bait UFL1 Cat. description Hein, Mann, Cell 2015
Category members IP bait PFKP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PFKM
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Phosphofructokinase_dom IPR000023 0.1
Category members 6-phosphofructokinase_euk IPR009161 0.1
Category members Phosphofructokinase IPR022953 0.1


Protein complexes (CORUM database) featuring PFKM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PFKM
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_57 REACTOME_GLYCOLYSIS 0 4.41
Category members GO Category GO:0006096 glycolysis Database 2.49
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members GO Category GO:0008022 protein C-terminus binding Database 1.43
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_63 BIOCARTA_PTDINS_PATHWAY 0 0.91
Category members GO Category GO:0019900 kinase binding Database 0.45
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0042593 glucose homeostasis Database 0.18
Category members Pathway Pathway_51 KEGG_PENTOSE_PHOSPHATE_PATHWAY 0 0.11
Category members Pathway Pathway_58 KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 0 0.1
Category members GO Category GO:0003872 6-phosphofructokinase activity Database 0.1
Category members GO Category GO:0005945 6-phosphofructokinase complex Database 0.1
Category members GO Category GO:0032024 positive regulation of insulin secretion Database 0.07
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members Pathway Pathway_64 KEGG_GALACTOSE_METABOLISM 0 0.04
Category members GO Category GO:0006002 fructose 6-phosphate metabolic process Database 0.02
Category members GO Category GO:0016324 apical plasma membrane Database 0
Category members GO Category GO:0046716 muscle cell cellular homeostasis Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0070061 fructose binding Database 0


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