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Query: PFKL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PFKL 1 7.277 -0.440 0.680 0.869 1.217 0.915

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PFKL Phosphorylation S775 1.454 1.553 _RTLS(ph)MDKGF_
PFKL Ubiquitylation K469 0.001 _GGSMLGTK(gl)R_
PFKL Ubiquitylation K677 0.140 -0.035 _NYGTK(gl)LGVK_
PFKL Ubiquitylation K616 0.588 -0.447 _MK(gl)TDIQR_
PFKL Ubiquitylation K365 -0.860 _AMDDK(gl)RFDEATQLR_

Background Information for PFKL:


Pubmed-PFKL »
Uniprot-PFKL »
Biogrid-PFKL »
ProteomicsDB-PFKL »

Tumorportal-PFKL »
COSMIC-PFKL »
GenomeRNAi-PFKL »
Genecards-PFKL


Protein-protein Interactions for PFKL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C9orf126;SCAI Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait TMED10 Cat. description Hein, Mann, Cell 2015
Category members IP bait TSNAX Cat. description Hein, Mann, Cell 2015
Category members IP bait PFKL Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PFKL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Phosphofructokinase_dom IPR000023 0.1
Category members 6-phosphofructokinase_euk IPR009161 0.1
Category members Phosphofructokinase IPR022953 0.1


Protein complexes (CORUM database) featuring PFKL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1335 SNW1 complex Database 3.59


Categories featuring PFKL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_57 REACTOME_GLYCOLYSIS 0 4.41
Category members GO Category GO:0006096 glycolysis Database 2.49
Category members Pathway Pathway_59 BIOCARTA_GLYCOLYSIS_PATHWAY 0 1.96
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members Pathway Pathway_63 BIOCARTA_PTDINS_PATHWAY 0 0.91
Category members GO Category GO:0019900 kinase binding Database 0.45
Category members GO Category GO:0051289 protein homotetramerization Database 0.44
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0030388 fructose 1,6-bisphosphate metabolic process Database 0.29
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0009749 response to glucose Database 0.13
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members Pathway Pathway_51 KEGG_PENTOSE_PHOSPHATE_PATHWAY 0 0.11
Category members Pathway Pathway_58 KEGG_FRUCTOSE_AND_MANNOSE_METABOLISM 0 0.1
Category members GO Category GO:0003872 6-phosphofructokinase activity Database 0.1
Category members GO Category GO:0005945 6-phosphofructokinase complex Database 0.1
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members Pathway Pathway_64 KEGG_GALACTOSE_METABOLISM 0 0.04
Category members GO Category GO:0006002 fructose 6-phosphate metabolic process Database 0.02
Category members GO Category GO:0046676 negative regulation of insulin secretion Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0048029 monosaccharide binding Database 0
Category members GO Category GO:0051259 protein oligomerization Database 0
Category members GO Category GO:0070061 fructose binding Database 0
Category members GO Category GO:0070095 fructose-6-phosphate binding Database 0


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