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Query: PER1

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PER1 0 -1.272 1.020 -0.450

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PER1 Ubiquitylation K295 -1.272 _DFTQEK(gl)SVFCR_

Background Information for PER1:


Pubmed-PER1 »
Uniprot-PER1 »
Biogrid-PER1 »
ProteomicsDB-PER1 »

Tumorportal-PER1 »
COSMIC-PER1 »
GenomeRNAi-PER1 »
Genecards-PER1


Protein-protein Interactions for PER1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CRY1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CSNK1D Cat. description Hein, Mann, Cell 2015
Category members IP bait CSNK1E Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARHGAP25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ARNTL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BBS7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C7orf60 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSNK1D Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CSNK1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait DQX1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GFOD1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GPR156 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait NXF2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDDC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PER1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait QPRT Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SSSCA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TEX264 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TXNIP Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PER1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PAS_fold_3 IPR013655 0.69
Category members PAS_fold IPR013767 0.27
Category members PAS IPR000014 0.23
Category members Period_circadian-like_C IPR022728 0.18


Protein complexes (CORUM database) featuring PER1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PER1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_157 REACTOME_CIRCADIAN_CLOCK 0 0.92
Category members Pathway Pathway_1275 KEGG_CIRCADIAN_RHYTHM_MAMMAL 0 0.74
Category members Pathway Pathway_748 REACTOME_BMAL1_CLOCK_NPAS2_ACTIVATES_CIRCADIAN_EXPRESSION 0 0.66
Category members GO Category GO:0032922 circadian regulation of gene expression Database 0.21
Category members GO Category GO:0009649 entrainment of circadian clock Database 0.1
Category members GO Category GO:0009416 response to light stimulus Database 0.06
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0000989 transcription factor binding transcription factor activity Database 0.01
Category members Pathway Pathway_1249 PID_CIRCADIAN_PATHWAY 0 0
Category members GO Category GO:0000978 RNA polymerase II core promoter proximal region sequence-specific DNA binding Database 0
Category members GO Category GO:0000988 protein binding transcription factor activity Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007623 circadian rhythm Database 0
Category members GO Category GO:0070888 E-box binding Database 0


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