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Query: PDIA6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PDIA6 0 1.855 1.060 -0.820 0.663 1.438 -1.234 0.073 0.167

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PDIA6 Ubiquitylation K289 0.793 _GFPTIK(gl)IFQK_
PDIA6 Phosphorylation S476 -0.194 0.149 _EPWDGRDGELPVEDDIDLS(ph)DVELDDLGKDEL_

Background Information for PDIA6:


Pubmed-PDIA6 »
Uniprot-PDIA6 »
Biogrid-PDIA6 »
ProteomicsDB-PDIA6 »

Tumorportal-PDIA6 »
COSMIC-PDIA6 »
GenomeRNAi-PDIA6 »
Genecards-PDIA6


Protein-protein Interactions for PDIA6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait HNRPLL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PDIA6 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in PDIA6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Disulphide_isomerase IPR005788 1.41
Category members Thioredoxin_domain IPR013766 0.49
Category members Thioredoxin-like_fold IPR012336 0.16


Protein complexes (CORUM database) featuring PDIA6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring PDIA6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0044267 cellular protein metabolic process Database 10.42
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0006457 protein folding Database 4.93
Category members GO Category GO:0005789 endoplasmic reticulum membrane Database 1.57
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0006987 activation of signaling protein activity involved in unfolded protein response Database 1.26
Category members GO Category GO:0003756 protein disulfide isomerase activity Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_147 REACTOME_UNFOLDED_PROTEIN_RESPONSE 0 1.08
Category members GO Category GO:0006662 glycerol ether metabolic process Database 0.79
Category members GO Category GO:0005793 endoplasmic reticulum-Golgi intermediate compartment Database 0.74
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members Pathway Pathway_146 REACTOME_DIABETES_PATHWAYS 0 0.39
Category members GO Category GO:0016853 isomerase activity Database 0.37
Category members Pathway Pathway_148 REACTOME_ACTIVATION_OF_CHAPERONE_GENES_BY_XBP1S 0 0.11
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0015035 protein disulfide oxidoreductase activity Database 0


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