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Query: PCF11

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
PCF11 3 7.262 -2.050 3.820 -1.031 1.582 3.004 -1.330 -0.783
PCF11 3 7.262 -2.050 3.820 0.235

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
PCF11 Phosphorylation S800 0.255 0.405 _RLS(ph)PISGSR_
PCF11 Phosphorylation S494 0.108 0.338 _SPIIHS(ph)PK_
PCF11 Phosphorylation T1530 -0.702 -0.561 _IDT(ph)PPACTEESIATPSEIK_
PCF11 Phosphorylation S705 -0.513 -0.572 _EEQRS(ph)PFNDRFPLK_
PCF11 Ubiquitylation K1278 0.074 _LLK(gl)TGILK_

Background Information for PCF11:


Pubmed-PCF11 »
Uniprot-PCF11 »
Biogrid-PCF11 »
ProteomicsDB-PCF11 »

Tumorportal-PCF11 »
COSMIC-PCF11 »
GenomeRNAi-PCF11 »
Genecards-PCF11


Protein-protein Interactions for PCF11
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait AK1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDK8 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDKN2AIP Cat. description Hein, Mann, Cell 2015
Category members IP bait CEP170P1 Cat. description Hein, Mann, Cell 2015
Category members IP bait EMC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait JUNB Cat. description Hein, Mann, Cell 2015
Category members IP bait MAPK3 Cat. description Hein, Mann, Cell 2015
Category members IP bait MRPL50 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPRD1B Cat. description Hein, Mann, Cell 2015
Category members IP bait SAMD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait USF1;usf1 Cat. description Hein, Mann, Cell 2015


Protein Domains in PCF11
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members RNA_pol_II-bd IPR006903 2.39
Category members CID_dom IPR006569 1.43
Category members ENTH_VHS IPR008942 0.96


Protein complexes (CORUM database) featuring PCF11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1141 CF IIAm complex (Cleavage factor IIAm complex) Database 2.57


Categories featuring PCF11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members Pathway Pathway_373 REACTOME_MRNA_PROCESSING 0 12.92
Category members Pathway Pathway_380 REACTOME_PROCESSING_OF_CAPPED_INTRON_CONTAINING_PRE_MRNA 0 12.24
Category members GO Category GO:0008380 RNA splicing Database 10.77
Category members Pathway Pathway_348 REACTOME_TRANSCRIPTION 0 9
Category members GO Category GO:0000398 mRNA splicing, via spliceosome Database 7.06
Category members Pathway Pathway_377 REACTOME_MRNA_SPLICING 0 6.99
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members Pathway Pathway_375 REACTOME_RNA_POL_II_TRANSCRIPTION 0 2.46
Category members Pathway Pathway_852 REACTOME_MRNA_3_END_PROCESSING 0 2.02
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members Pathway Pathway_854 REACTOME_CLEAVAGE_OF_GROWING_TRANSCRIPT_IN_THE_TERMINATION_REGION_ 0 0.91
Category members GO Category GO:0031124 mRNA 3'-end processing Database 0.91
Category members GO Category GO:0006369 termination of RNA polymerase II transcription Database 0.87
Category members Pathway Pathway_855 REACTOME_PROCESSING_OF_INTRONLESS_PRE_MRNAS 0 0.29
Category members GO Category GO:0005849 mRNA cleavage factor complex Database 0.13
Category members Pathway Pathway_853 REACTOME_PROCESSING_OF_CAPPED_INTRONLESS_PRE_MRNA 0 0.05
Category members GO Category GO:0006379 mRNA cleavage Database 0


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