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Query: P4HB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
P4HB 2 9.165 -1.530 2.950 0.990 0.813 0.711 0.548 0.459

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
P4HB Ubiquitylation K81 -0.179 2.873 _LAK(gl)VDATEESDLAQQYGVR_
P4HB Ubiquitylation K103 1.407 _GYPTIK(gl)FFR_
P4HB Ubiquitylation K385 -0.726 0.916 _NFEDVAFDEK(gl)K_
P4HB Ubiquitylation K386 -0.726 0.916 _NFEDVAFDEK(gl)K_
P4HB Ubiquitylation K65 -1.515 -0.862 _ALAPEYAK(gl)AAGK_
P4HB Ubiquitylation K69 -0.948 _ALAPEYAKAAGK(gl)_

Background Information for P4HB:


Pubmed-P4HB »
Uniprot-P4HB »
Biogrid-P4HB »
ProteomicsDB-P4HB »

Tumorportal-P4HB »
COSMIC-P4HB »
GenomeRNAi-P4HB »
Genecards-P4HB


Protein-protein Interactions for P4HB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C1orf9;SUCO Cat. description Hein, Mann, Cell 2015
Category members IP bait CCDC6 Cat. description Hein, Mann, Cell 2015
Category members IP bait CPSF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait EDEM1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FIP1L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RBM8A Cat. description Hein, Mann, Cell 2015
Category members IP bait SYMPK Cat. description Hein, Mann, Cell 2015
Category members IP bait TAPT1 Cat. description Hein, Mann, Cell 2015
Category members IP bait WBP11 Cat. description Hein, Mann, Cell 2015
Category members IP bait GXYLT1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HA3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait P4HB Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM4 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in P4HB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Disulphide_isomerase IPR005788 1.41
Category members Thioredoxin_domain IPR013766 0.49
Category members Prot_disulphide_isomerase IPR005792 0.42
Category members Calsequestrin IPR001393 0.3
Category members Thioredoxin-like_fold IPR012336 0.16
Category members AhpC/TSA IPR000866 0.13


Protein complexes (CORUM database) featuring P4HB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 472 Prolyl 4-hydroxylase (alpha(I)-type) Database 0.13
Category members Corum 474 Prolyl 4-hydroxylase (alpha(III)-type) Database 0


Categories featuring P4HB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0006457 protein folding Database 4.93
Category members Pathway Pathway_309 ST_INTEGRIN_SIGNALING_PATHWAY 0 1.35
Category members GO Category GO:0003756 protein disulfide isomerase activity Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0006662 glycerol ether metabolic process Database 0.79
Category members GO Category GO:0005793 endoplasmic reticulum-Golgi intermediate compartment Database 0.74
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016853 isomerase activity Database 0.37
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0030198 extracellular matrix organization Database 0.26
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members Pathway Pathway_415 REACTOME_EXTRACELLULAR_MATRIX_ORGANIZATION 0 0.09
Category members GO Category GO:0034976 response to endoplasmic reticulum stress Database 0.06
Category members GO Category GO:0016209 antioxidant activity Database 0.06
Category members GO Category GO:0045454 cell redox homeostasis Database 0.05
Category members Pathway Pathway_1289 BIOCARTA_VITCB_PATHWAY 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_407 BIOCARTA_HIF_PATHWAY 0 0
Category members Pathway Pathway_414 REACTOME_COLLAGEN_FORMATION 0 0
Category members Pathway Pathway_490 REACTOME_LIPID_DIGESTION_MOBILIZATION_AND_TRANSPORT 0 0
Category members Pathway Pathway_491 REACTOME_CHYLOMICRON_MEDIATED_LIPID_TRANSPORT 0 0
Category members Pathway Pathway_492 REACTOME_LIPOPROTEIN_METABOLISM 0 0
Category members GO Category GO:0004656 procollagen-proline 4-dioxygenase activity Database 0
Category members GO Category GO:0005788 endoplasmic reticulum lumen Database 0
Category members GO Category GO:0015035 protein disulfide oxidoreductase activity Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0018401 peptidyl-proline hydroxylation to 4-hydroxy-L-proline Database 0
Category members GO Category GO:0042157 lipoprotein metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0
Category members GO Category GO:0071456 cellular response to hypoxia Database 0


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