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Query: OCRL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
OCRL 0 2.306 0.410 -0.320
OCRL 0 2.306 0.410 -0.320 0.052 0.039 0.310

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
OCRL Ubiquitylation K391 1.116 0.789 _RNQDYK(gl)DICAR_
OCRL Ubiquitylation K127 -0.129 _AQSQLLVPEQK(gl)DSSSWYQK_
OCRL Ubiquitylation K701 -0.835 _EVPVTK(gl)LIDLEK_
OCRL Ubiquitylation K135 -0.111 _DSSSWYQK(gl)LDTK_

Background Information for OCRL:


Pubmed-OCRL »
Uniprot-OCRL »
Biogrid-OCRL »
ProteomicsDB-OCRL »

Tumorportal-OCRL »
COSMIC-OCRL »
GenomeRNAi-OCRL »
Genecards-OCRL


Protein-protein Interactions for OCRL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait SEC24C Cat. description Hein, Mann, Cell 2015
Category members IP bait C16orf70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM109A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait FAM109B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IL1R2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OCRL Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RAB6B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNX21 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPCN2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in OCRL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Rho_GTPase_activation_prot IPR008936 0.53
Category members IPPc IPR000300 0.1
Category members RhoGAP_dom IPR000198 0
Category members Endo/exonuclease/phosphatase IPR005135 0


Protein complexes (CORUM database) featuring OCRL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring OCRL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_474 REACTOME_MEMBRANE_TRAFFICKING 0 1.14
Category members Pathway Pathway_475 REACTOME_TRANS_GOLGI_NETWORK_VESICLE_BUDDING 0 0.98
Category members Pathway Pathway_520 REACTOME_GOLGI_ASSOCIATED_VESICLE_BIOGENESIS 0 0.78
Category members GO Category GO:0031901 early endosome membrane Database 0.58
Category members Pathway Pathway_501 REACTOME_SYNTHESIS_OF_PIPS_AT_THE_GOLGI_MEMBRANE 0 0.46
Category members GO Category GO:0030670 phagocytic vesicle membrane Database 0.37
Category members GO Category GO:0007264 small GTPase mediated signal transduction Database 0.37
Category members GO Category GO:0046856 phosphatidylinositol dephosphorylation Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0005622 intracellular Database 0.32
Category members Pathway Pathway_106 KEGG_INOSITOL_PHOSPHATE_METABOLISM 0 0.28
Category members GO Category GO:0051056 regulation of small GTPase mediated signal transduction Database 0.25
Category members GO Category GO:0004439 phosphatidylinositol-4,5-bisphosphate 5-phosphatase activity Database 0.23
Category members GO Category GO:0001701 in utero embryonic development Database 0.2
Category members GO Category GO:0005905 coated pit Database 0.17
Category members GO Category GO:0005802 trans-Golgi network Database 0.13
Category members GO Category GO:0032314 regulation of Rac GTPase activity Database 0.11
Category members GO Category GO:0048365 Rac GTPase binding Database 0.1
Category members GO Category GO:0030136 clathrin-coated vesicle Database 0.06
Category members GO Category GO:0006661 phosphatidylinositol biosynthetic process Database 0.06
Category members GO Category GO:0005798 Golgi-associated vesicle Database 0.04
Category members Pathway Pathway_103 REACTOME_PI_METABOLISM 0 0.04
Category members Pathway Pathway_100 REACTOME_PHOSPHOLIPID_METABOLISM 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_488 KEGG_PHOSPHATIDYLINOSITOL_SIGNALING_SYSTEM 0 0
Category members Pathway Pathway_519 REACTOME_SIGNALING_BY_RHO_GTPASES 0 0
Category members GO Category GO:0001750 photoreceptor outer segment Database 0
Category members GO Category GO:0005795 Golgi stack Database 0
Category members GO Category GO:0006629 lipid metabolic process Database 0
Category members GO Category GO:0006644 phospholipid metabolic process Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0030675 Rac GTPase activator activity Database 0
Category members GO Category GO:0032855 positive regulation of Rac GTPase activity Database 0
Category members GO Category GO:0042384 cilium assembly Database 0
Category members GO Category GO:0043647 inositol phosphate metabolic process Database 0


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