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Query: NUMB

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NUMB 0 1.159 0.310 0.050

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NUMB Phosphorylation T436 0.878 _RT(ph)PSEADRWLEEVSK_
NUMB Ubiquitylation K63 0.281 _GMHICEDAVK(gl)R_

Background Information for NUMB:


Pubmed-NUMB »
Uniprot-NUMB »
Biogrid-NUMB »
ProteomicsDB-NUMB »

Tumorportal-NUMB »
COSMIC-NUMB »
GenomeRNAi-NUMB »
Genecards-NUMB


Protein-protein Interactions for NUMB
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANLN Cat. description Hein, Mann, Cell 2015
Category members IP bait ATP6AP2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTB Cat. description Hein, Mann, Cell 2015
Category members IP bait CLTC Cat. description Hein, Mann, Cell 2015
Category members IP bait DBN1 Cat. description Hein, Mann, Cell 2015
Category members IP bait FLNB Cat. description Hein, Mann, Cell 2015
Category members IP bait GAK Cat. description Hein, Mann, Cell 2015
Category members IP bait GTSE1 Cat. description Hein, Mann, Cell 2015
Category members IP bait IGBP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1107 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH10 Cat. description Hein, Mann, Cell 2015
Category members IP bait OSGEP Cat. description Hein, Mann, Cell 2015
Category members IP bait AP2M1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait COL10A1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait KBTBD7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait STAMBPL1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TULP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait UNC5CL Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NUMB
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members PTB/PI_dom IPR006020 0
Category members Numb_domain IPR010449 0
Category members PTB IPR013625 0
Category members Numb/numb-like IPR016698 0


Protein complexes (CORUM database) featuring NUMB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 247 RalBP1-CCNB1-AP2A-NUMB-EPN1 complex Database 0
Category members Corum 3172 NUMB-TP53-MDM2 complex Database 0


Categories featuring NUMB
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members Pathway Pathway_1075 REACTOME_L1CAM_INTERACTIONS 0 1.32
Category members GO Category GO:0005769 early endosome Database 1.26
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members Pathway Pathway_507 PID_MET_PATHWAY 0 0.82
Category members GO Category GO:0008013 beta-catenin binding Database 0.35
Category members Pathway Pathway_117 REACTOME_SIGNALING_BY_NOTCH 0 0.33
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members Pathway Pathway_849 PID_NOTCH_PATHWAY 0 0.29
Category members GO Category GO:0007405 neuroblast proliferation Database 0.28
Category members GO Category GO:0045296 cadherin binding Database 0.26
Category members Pathway Pathway_789 REACTOME_SIGNALING_BY_NOTCH1 0 0.22
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0007409 axonogenesis Database 0.13
Category members GO Category GO:0050769 positive regulation of neurogenesis Database 0.06
Category members GO Category GO:0007219 Notch signaling pathway Database 0.05
Category members Pathway Pathway_1136 REACTOME_RECYCLING_PATHWAY_OF_L1 0 0.04
Category members GO Category GO:0016323 basolateral plasma membrane Database 0.04
Category members GO Category GO:0019897 extrinsic to plasma membrane Database 0.03
Category members GO Category GO:0045294 alpha-catenin binding Database 0.03
Category members Pathway Pathway_831 REACTOME_ACTIVATED_NOTCH1_TRANSMITS_SIGNAL_TO_THE_NUCLEUS 0 0
Category members Pathway Pathway_892 KEGG_NOTCH_SIGNALING_PATHWAY 0 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0021670 lateral ventricle development Database 0
Category members GO Category GO:0021849 neuroblast division in subventricular zone Database 0
Category members GO Category GO:0030862 positive regulation of polarized epithelial cell differentiation Database 0
Category members GO Category GO:0030900 forebrain development Database 0
Category members GO Category GO:0034332 adherens junction organization Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0045746 negative regulation of Notch signaling pathway Database 0
Category members GO Category GO:0060487 lung epithelial cell differentiation Database 0


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