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Query: NR2C2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NR2C2 1 4.509 -2.470 4.780

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NR2C2 Phosphorylation T371 0.442 -0.117 _DQST(ph)PIIEVEGPLLSDTHVTFK_
NR2C2 Ubiquitylation K250 -0.596 _SPLIATPTFVADK(gl)DGAR_
NR2C2 Phosphorylation S370 -0.170 _DQS(ph)TPIIEVEGPLLSDTHVTFK_

Background Information for NR2C2:


Pubmed-NR2C2 »
Uniprot-NR2C2 »
Biogrid-NR2C2 »
ProteomicsDB-NR2C2 »

Tumorportal-NR2C2 »
COSMIC-NR2C2 »
GenomeRNAi-NR2C2 »
Genecards-NR2C2


Protein-protein Interactions for NR2C2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait NR2C2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CD70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NR2C2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Nucl_hrmn_rcpt_lig-bd_core IPR000536 0
Category members Znf_hrmn_rcpt IPR001628 0
Category members Str_hrmn_rcpt IPR001723 0
Category members Nucl_hormone_rcpt_ligand-bd IPR008946 0


Protein complexes (CORUM database) featuring NR2C2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NR2C2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0010467 gene expression Database INF
Category members GO Category GO:0003713 transcription coactivator activity Database 3.68
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members Pathway Pathway_308 PID_AR_TF_PATHWAY 0 0.86
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members Pathway Pathway_983 ST_P38_MAPK_PATHWAY 0 0.34
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0046982 protein heterodimerization activity Database 0.28
Category members GO Category GO:0006367 transcription initiation from RNA polymerase II promoter Database 0.25
Category members GO Category GO:0051321 meiotic cell cycle Database 0.23
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0021549 cerebellum development Database 0.14
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0030154 cell differentiation Database 0.06
Category members Pathway Pathway_1021 ST_TUMOR_NECROSIS_FACTOR_PATHWAY 0 0
Category members Pathway Pathway_21 ST_JNK_MAPK_PATHWAY 0 0
Category members GO Category GO:0003707 steroid hormone receptor activity Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0007283 spermatogenesis Database 0
Category members GO Category GO:0007399 nervous system development Database 0
Category members GO Category GO:0040019 positive regulation of embryonic development Database 0
Category members GO Category GO:0043401 steroid hormone mediated signaling pathway Database 0
Category members GO Category GO:0048520 positive regulation of behavior Database 0


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