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Query: NPC1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NPC1 0 1.359 0.620 -0.700 0.275 0.103

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NPC1 Ubiquitylation K1191 0.981 _AFTVSMK(gl)GSR_

Background Information for NPC1:


Pubmed-NPC1 »
Uniprot-NPC1 »
Biogrid-NPC1 »
ProteomicsDB-NPC1 »

Tumorportal-NPC1 »
COSMIC-NPC1 »
GenomeRNAi-NPC1 »
Genecards-NPC1


Protein-protein Interactions for NPC1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait IL17RC Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PTPRK Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TPRA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NPC1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SSD IPR000731 0.17
Category members Patched IPR003392 0.09
Category members NP_C_type IPR004765 0.08
Category members MMPL_dom IPR004869 0


Protein complexes (CORUM database) featuring NPC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NPC1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005576 extracellular region Database 10.9
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0005635 nuclear envelope Database 7.22
Category members GO Category GO:0005887 integral to plasma membrane Database 1.69
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0005765 lysosomal membrane Database 0.82
Category members GO Category GO:0042493 response to drug Database 0.66
Category members GO Category GO:0005783 endoplasmic reticulum Database 0.62
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0048471 perinuclear region of cytoplasm Database 0.39
Category members GO Category GO:0006897 endocytosis Database 0.31
Category members GO Category GO:0005768 endosome Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0006486 protein glycosylation Database 0.21
Category members GO Category GO:0004888 transmembrane signaling receptor activity Database 0.15
Category members GO Category GO:0045121 membrane raft Database 0.11
Category members GO Category GO:0071383 cellular response to steroid hormone stimulus Database 0.08
Category members GO Category GO:0008203 cholesterol metabolic process Database 0.08
Category members GO Category GO:0015485 cholesterol binding Database 0.04
Category members GO Category GO:0008158 hedgehog receptor activity Database 0.04
Category members GO Category GO:0031982 vesicle Database 0.01
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members Disease phenotype Niemann-Pick_disease_type_C_adult_neurologic_onset Niemann-Pick disease type C adult neurologic onset Database 0
Category members Disease phenotype Niemann-Pick_disease_type_C_juvenile_neurologic_onset Niemann-Pick disease type C juvenile neurologic onset Database 0
Category members Disease phenotype Niemann-Pick_disease_type_C_late_infantile_neurologic_onset Niemann-Pick disease type C late infantile neurologic onset Database 0
Category members Disease phenotype Niemann-Pick_disease_type_C_severe_early_infantile_neurologic_onset Niemann-Pick disease type C severe early infantile neurologic onset Database 0
Category members Disease phenotype Niemann-Pick_disease_type_C_severe_perinatal_form Niemann-Pick disease type C severe perinatal form Database 0
Category members GO Category GO:0004872 receptor activity Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0006914 autophagy Database 0
Category members GO Category GO:0007041 lysosomal transport Database 0
Category members GO Category GO:0007628 adult walking behavior Database 0
Category members GO Category GO:0008206 bile acid metabolic process Database 0
Category members GO Category GO:0015248 sterol transporter activity Database 0
Category members GO Category GO:0016242 negative regulation of macroautophagy Database 0
Category members GO Category GO:0030301 cholesterol transport Database 0
Category members GO Category GO:0031902 late endosome membrane Database 0
Category members GO Category GO:0033344 cholesterol efflux Database 0
Category members GO Category GO:0042632 cholesterol homeostasis Database 0
Category members GO Category GO:0046686 response to cadmium ion Database 0
Category members GO Category GO:0060548 negative regulation of cell death Database 0
Category members GO Category GO:0071404 cellular response to low-density lipoprotein particle stimulus Database 0


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