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Query: NFE2L2

This is a cancer-associated gene according to the Broad and Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NFE2L2 0 -0.831 1.610 -1.200

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NFE2L2 Ubiquitylation K65 -0.831 _QEQLQK(gl)EQEK_

Background Information for NFE2L2:


Pubmed-NFE2L2 »
Uniprot-NFE2L2 »
Biogrid-NFE2L2 »
ProteomicsDB-NFE2L2 »

Tumorportal-NFE2L2 »
COSMIC-NFE2L2 »
GenomeRNAi-NFE2L2 »
Genecards-NFE2L2


Protein-protein Interactions for NFE2L2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MAFF Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NFE2L2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Serpin_dom IPR023796 0.21
Category members bZIP IPR004827 0
Category members TF_DNA-bd IPR008917 0


Protein complexes (CORUM database) featuring NFE2L2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 5805 PGAM5-KEAP1-NRF2 complex Database 0


Categories featuring NFE2L2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0019904 protein domain specific binding Database 1.85
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0030968 endoplasmic reticulum unfolded protein response Database 1.35
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0001102 RNA polymerase II activating transcription factor binding Database 0.31
Category members GO Category GO:0045893 positive regulation of transcription, DNA-dependent Database 0.28
Category members GO Category GO:0043161 proteasome-mediated ubiquitin-dependent protein catabolic process Database 0.23
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0016567 protein ubiquitination Database 0.07
Category members GO Category GO:0036003 positive regulation of transcription from RNA polymerase II promoter in response to stress Database 0.04
Category members GO Category GO:0071356 cellular response to tumor necrosis factor Database 0.03
Category members GO Category GO:0070301 cellular response to hydrogen peroxide Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0010499 proteasomal ubiquitin-independent protein catabolic process Database 0
Category members GO Category GO:0030194 positive regulation of blood coagulation Database 0
Category members GO Category GO:0034599 cellular response to oxidative stress Database 0
Category members GO Category GO:0045995 regulation of embryonic development Database 0
Category members GO Category GO:0060548 negative regulation of cell death Database 0


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