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Query: NEK6

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NEK6 0 -1.353 0.580 -1.160

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NEK6 Ubiquitylation K277 -1.179 -0.174 _IEQCDYPPLPGEHYSEK(gl)LR_

Background Information for NEK6:


Pubmed-NEK6 »
Uniprot-NEK6 »
Biogrid-NEK6 »
ProteomicsDB-NEK6 »

Tumorportal-NEK6 »
COSMIC-NEK6 »
GenomeRNAi-NEK6 »
Genecards-NEK6


Protein-protein Interactions for NEK6
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait IL13RA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LAMP3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NEK6
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring NEK6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring NEK6
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0007077 mitotic nuclear envelope disassembly Database 5.8
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0006915 apoptotic process Database 2.12
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0030071 regulation of mitotic metaphase/anaphase transition Database 0.48
Category members GO Category GO:0005815 microtubule organizing center Database 0.39
Category members GO Category GO:0019901 protein kinase binding Database 0.37
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0051225 spindle assembly Database 0.25
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0018105 peptidyl-serine phosphorylation Database 0.18
Category members GO Category GO:0000910 cytokinesis Database 0.15
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0019894 kinesin binding Database 0.02
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members GO Category GO:0000287 magnesium ion binding Database 0
Category members GO Category GO:0004871 signal transducer activity Database 0
Category members GO Category GO:0007165 signal transduction Database 0
Category members GO Category GO:0007346 regulation of mitotic cell cycle Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0031572 G2 DNA damage checkpoint Database 0
Category members GO Category GO:0043123 positive regulation of I-kappaB kinase/NF-kappaB signaling Database 0


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