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Query: NEK2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
NEK2 0 0.118 -0.540 0.300

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
NEK2 Ubiquitylation K409 -0.182 _SENSESQLTSKSK(gl)_
NEK2 Ubiquitylation K359 -0.192 _NYSLLK(gl)ER_
NEK2 Ubiquitylation K353 -1.746 _AENLLK(gl)NYSLLK_
NEK2 Ubiquitylation K152 -2.296 _DLKPANVFLDGK(gl)QNVK_

Background Information for NEK2:


Pubmed-NEK2 »
Uniprot-NEK2 »
Biogrid-NEK2 »
ProteomicsDB-NEK2 »

Tumorportal-NEK2 »
COSMIC-NEK2 »
GenomeRNAi-NEK2 »
Genecards-NEK2


Protein-protein Interactions for NEK2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait ANAPC15 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait ANAPC2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC16 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC23 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC26 Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1430 Cat. description Hein, Mann, Cell 2015
Category members IP bait NEK2 Cat. description Hein, Mann, Cell 2015
Category members IP bait PPP2R1A Cat. description Hein, Mann, Cell 2015
Category members IP bait BFSP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C16orf87 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in NEK2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring NEK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1932 NEK2-NEK11 complex Database 0


Categories featuring NEK2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members Pathway Pathway_320 REACTOME_CELL_CYCLE 0 11.08
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Pathway Pathway_317 REACTOME_CELL_CYCLE_MITOTIC 0 4.82
Category members GO Category GO:0043234 protein complex Database 2.73
Category members GO Category GO:0000776 kinetochore Database 2.24
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0000794 condensed nuclear chromosome Database 1.58
Category members Pathway Pathway_836 REACTOME_APC_CDC20_MEDIATED_DEGRADATION_OF_NEK2A 0 1.58
Category members GO Category GO:0005874 microtubule Database 1.21
Category members Pathway Pathway_968 PID_FOXM1_PATHWAY 0 0.8
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members Pathway Pathway_727 REACTOME_MITOTIC_G2_G2_M_PHASES 0 0.46
Category members Pathway Pathway_728 REACTOME_RECRUITMENT_OF_MITOTIC_CENTROSOME_PROTEINS_AND_COMPLEXES 0 0.4
Category members GO Category GO:0030496 midbody Database 0.39
Category members GO Category GO:0000922 spindle pole Database 0.35
Category members GO Category GO:0019903 protein phosphatase binding Database 0.33
Category members Pathway Pathway_730 REACTOME_LOSS_OF_NLP_FROM_MITOTIC_CENTROSOMES 0 0.33
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0000777 condensed chromosome kinetochore Database 0.32
Category members GO Category GO:0051225 spindle assembly Database 0.25
Category members GO Category GO:0046777 protein autophosphorylation Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0051299 centrosome separation Database 0.18
Category members GO Category GO:0007059 chromosome segregation Database 0.13
Category members GO Category GO:0007088 regulation of mitosis Database 0.07
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0043392 negative regulation of DNA binding Database 0.01
Category members GO Category GO:0007126 meiosis Database 0.01
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Disease phenotype Retinitis_pigmentosa Retinitis pigmentosa Database 0
Category members GO Category GO:0000070 mitotic sister chromatid segregation Database 0
Category members GO Category GO:0001824 blastocyst development Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0046602 regulation of mitotic centrosome separation Database 0
Category members GO Category GO:0046872 metal ion binding Database 0
Category members GO Category GO:0051988 regulation of attachment of spindle microtubules to kinetochore Database 0


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