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Query: MYH11

This is a cancer-associated gene according to the Sanger cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MYH11 0 0.911 0.030 0.200 -0.067 0.778

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence

Background Information for MYH11:


Pubmed-MYH11 »
Uniprot-MYH11 »
Biogrid-MYH11 »
ProteomicsDB-MYH11 »

Tumorportal-MYH11 »
COSMIC-MYH11 »
GenomeRNAi-MYH11 »
Genecards-MYH11


Protein-protein Interactions for MYH11
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MYH11 Cat. description Hein, Mann, Cell 2015
Category members IP bait GDF9 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MPP1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait OVCA2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RWDD2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MYH11
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Myosin_head_motor_dom IPR001609 0.17
Category members t-SNARE IPR010989 0.04
Category members IQ_motif_EF-hand-BS IPR000048 0
Category members Myosin_tail IPR002928 0
Category members Myosin_N IPR004009 0
Category members Prefoldin IPR009053 0


Protein complexes (CORUM database) featuring MYH11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MYH11
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0042470 melanosome Database 5.59
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members Human mutations Sanger_cancer_genes Sanger cancer genes Database 4.88
Category members Pathway Pathway_413 KEGG_TIGHT_JUNCTION 0 2.08
Category members GO Category GO:0016192 vesicle-mediated transport Database 1.1
Category members Pathway Pathway_673 REACTOME_AXON_GUIDANCE 0 1.06
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members Pathway Pathway_674 REACTOME_SEMAPHORIN_INTERACTIONS 0 0.96
Category members GO Category GO:0005516 calmodulin binding Database 0.74
Category members GO Category GO:0016020 membrane Database 0.52
Category members GO Category GO:0016459 myosin complex Database 0.38
Category members Pathway Pathway_42 REACTOME_DEVELOPMENTAL_BIOLOGY 0 0.32
Category members GO Category GO:0003774 motor activity Database 0.2
Category members GO Category GO:0007411 axon guidance Database 0.13
Category members GO Category GO:0001725 stress fiber Database 0.04
Category members Pathway Pathway_160 KEGG_VASCULAR_SMOOTH_MUSCLE_CONTRACTION 0 0.01
Category members Pathway Pathway_1014 KEGG_VIRAL_MYOCARDITIS 0 0
Category members Pathway Pathway_1032 REACTOME_SEMA4D_IN_SEMAPHORIN_SIGNALING 0 0
Category members Pathway Pathway_1035 REACTOME_SEMA4D_INDUCED_CELL_MIGRATION_AND_GROWTH_CONE_COLLAPSE 0 0
Category members Pathway Pathway_949 REACTOME_SMOOTH_MUSCLE_CONTRACTION 0 0
Category members Pathway Pathway_950 REACTOME_MUSCLE_CONTRACTION 0 0
Category members Disease phenotype Acute_myeloid_leukemia_with_abnormal_bone_marrow_eosinophils_inv(16)(p13q22)_or_t(16;16)(p13;q22) Acute myeloid leukemia with abnormal bone marrow eosinophils inv(16)(p13q22) or t(16;16)(p13;q22) Database 0
Category members Disease phenotype Familial_thoracic_aortic_aneurysm_and_aortic_dissection Familial thoracic aortic aneurysm and aortic dissection Database 0
Category members GO Category GO:0005859 muscle myosin complex Database 0
Category members GO Category GO:0006936 muscle contraction Database 0
Category members GO Category GO:0006939 smooth muscle contraction Database 0
Category members GO Category GO:0008307 structural constituent of muscle Database 0
Category members GO Category GO:0030241 skeletal muscle myosin thick filament assembly Database 0
Category members GO Category GO:0030485 smooth muscle contractile fiber Database 0
Category members GO Category GO:0032982 myosin filament Database 0
Category members GO Category GO:0048251 elastic fiber assembly Database 0
Category members GO Category GO:0048739 cardiac muscle fiber development Database 0


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