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Query: MTA2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MTA2 0 5.366 -1.360 1.910 0.507 0.478 0.899 0.023 0.072

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MTA2 Phosphorylation S54 0.469 0.399 _DISSS(ph)LNSLADSNAR_
MTA2 Ubiquitylation K152 0.194 0.043 _VGCK(gl)YQAEIPDRLVEGESDNR_
MTA2 Phosphorylation S435 -0.289 _GHLSRPEAQSLS(ph)PYTTSANR_
MTA2 Phosphorylation T534 -0.765 _DLVAQAPLKPKT(ph)PR_
MTA2 Ubiquitylation K32 0.007 _RIEELNK(gl)TANGNVEAK_
MTA2 Ubiquitylation K71 0.012 _EFEEESK(gl)QPGVSEQQR_
MTA2 Ubiquitylation K173 -0.127 _LVEGESDNRNQQK(gl)MEMK_
MTA2 Ubiquitylation K177 -0.885 _MEMK(gl)VWDPDNPLTDR_
MTA2 Ubiquitylation K320 0.565 _TTDRYIQQK(gl)R_
MTA2 Ubiquitylation K405 -0.377 _YGGLK(gl)TPTQLEGATR_
MTA2 Ubiquitylation K508 -0.512 _TPLK(gl)IHPLVR_
MTA2 Ubiquitylation K531 -0.796 _DLVAQAPLK(gl)PK_
MTA2 Ubiquitylation K559 0.516 _GLGGIMVK(gl)R_
MTA2 Ubiquitylation K611 -1.680 _LNPADAPNPVVFVATK(gl)DTR_

Background Information for MTA2:


Pubmed-MTA2 »
Uniprot-MTA2 »
Biogrid-MTA2 »
ProteomicsDB-MTA2 »

Tumorportal-MTA2 »
COSMIC-MTA2 »
GenomeRNAi-MTA2 »
Genecards-MTA2


Protein-protein Interactions for MTA2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CBX1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MTA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait RACGAP1 Cat. description Hein, Mann, Cell 2015
Category members IP bait BCL2L11 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait BCL2L14 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait C9orf25 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CCDC69 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDK18 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CGB2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CPNE5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GATAD2A Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GATAD2B Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HDAC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait IKZF1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait L3MBTL2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MBD3L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait PHF20L1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait RBBP7 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TCF19 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TRIM35 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZBED1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZDHHC1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF219 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ZNF800 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MTA2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members SANT/Myb IPR001005 2.18
Category members BAH_dom IPR001025 0.62
Category members ELM2_dom IPR000949 0.51
Category members Znf_GATA IPR000679 0.29
Category members Homeodomain-like IPR009057 0


Protein complexes (CORUM database) featuring MTA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 282 SNF2h-cohesin-NuRD complex Database 6.11
Category members Corum 778 LARC complex (LCR-associated remodeling complex) Database 5.04
Category members Corum 1257 ALL-1 supercomplex Database 4.3
Category members Corum 659 MeCP1 complex Database 4.17
Category members Corum 685 MeCP1 complex Database 4.17
Category members Corum 62 MeCP1 complex Database 3.53
Category members Corum 646 HDAC1-associated protein complex Database 3.34
Category members Corum 649 HDAC1-associated core complex cII Database 3.34
Category members Corum 61 Mi2/NuRD complex Database 2.87
Category members Corum 650 HDAC2-asscociated core complex Database 2.26
Category members Corum 888 MTA2 complex Database 2.24
Category members Corum 632 Anti-HDAC2 complex Database 2.11
Category members Corum 1495 PID complex Database 1.68
Category members Corum 41 Mi-2/NuRD-MTA2 complex Database 0.67


Categories featuring MTA2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0003682 chromatin binding Database 6.07
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members GO Category GO:0016581 NuRD complex Database 1.15
Category members Pathway Pathway_943 PID_HDAC_CLASSI_PATHWAY 0 1.08
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0006333 chromatin assembly or disassembly Database 0.48
Category members GO Category GO:0001103 RNA polymerase II repressing transcription factor binding Database 0.36
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0006306 DNA methylation Database 0.22
Category members GO Category GO:0005667 transcription factor complex Database 0.19
Category members GO Category GO:0043565 sequence-specific DNA binding Database 0.18
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0000122 negative regulation of transcription from RNA polymerase II promoter Database 0.02
Category members GO Category GO:0000989 transcription factor binding transcription factor activity Database 0.01
Category members GO Category GO:0044212 transcription regulatory region DNA binding Database 0
Category members GO Category GO:0000118 histone deacetylase complex Database 0
Category members GO Category GO:0001085 RNA polymerase II transcription factor binding Database 0
Category members GO Category GO:0004407 histone deacetylase activity Database 0
Category members GO Category GO:0006355 regulation of transcription, DNA-dependent Database 0
Category members GO Category GO:0016575 histone deacetylation Database 0


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