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Query: MFN2

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MFN2 1 2.687 0.100 0.320 0.028

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MFN2 Ubiquitylation K84 1.579 0.761 _GYLSK(gl)VR_
MFN2 Ubiquitylation K420 1.342 0.355 _IK(gl)QITEEVER_
MFN2 Ubiquitylation K416 -0.150 0.279 _QLELLAQDYK(gl)LR_
MFN2 Ubiquitylation K357 0.235 -0.035 _TK(gl)FEQHTVR_
MFN2 Ubiquitylation K366 -0.376 _AK(gl)QIAEAVR_
MFN2 Ubiquitylation K560 -0.434 _FLGPK(gl)NSRR_
MFN2 Ubiquitylation K316 -0.574 _IQK(gl)AQGMPEGGGALAEGFQVR_
MFN2 Ubiquitylation K720 -0.575 _ENLEQEIAAMNKK(gl)_
MFN2 Ubiquitylation K719 -0.768 _ENLEQEIAAMNK(gl)K_
MFN2 Ubiquitylation K463 -0.905 _VYK(gl)NELHR_
MFN2 Ubiquitylation K730 -1.137 _KIEVLDSLQSK(gl)AK_

Background Information for MFN2:


Pubmed-MFN2 »
Uniprot-MFN2 »
Biogrid-MFN2 »
ProteomicsDB-MFN2 »

Tumorportal-MFN2 »
COSMIC-MFN2 »
GenomeRNAi-MFN2 »
Genecards-MFN2


Protein-protein Interactions for MFN2
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait 5-Mar Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait GHITM Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MFN1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait REEP5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait VSIG1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MFN2
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members P-loop_NTPase IPR027417 2.83
Category members Dynamin_GTPase IPR001401 0.36
Category members Fzo/mitofusin_HR2 IPR006884 0


Protein complexes (CORUM database) featuring MFN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MFN2
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0016021 integral to membrane Database 7.67
Category members GO Category GO:0031625 ubiquitin protein ligase binding Database 2.54
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0005741 mitochondrial outer membrane Database 0.46
Category members Pathway Pathway_53 REACTOME_HEMOSTASIS 0 0.4
Category members GO Category GO:0007596 blood coagulation Database 0.4
Category members GO Category GO:0006184 GTP catabolic process Database 0.29
Category members Disease phenotype Autosomal_dominant_optic_atrophy_plus_syndrome Autosomal dominant optic atrophy plus syndrome Database 0.28
Category members GO Category GO:0008053 mitochondrial fusion Database 0.27
Category members GO Category GO:0046580 negative regulation of Ras protein signal transduction Database 0.23
Category members GO Category GO:0005525 GTP binding Database 0.16
Category members GO Category GO:0003924 GTPase activity Database 0.16
Category members GO Category GO:0006626 protein targeting to mitochondrion Database 0.11
Category members GO Category GO:0001825 blastocyst formation Database 0.09
Category members GO Category GO:0008219 cell death Database 0.08
Category members Pathway Pathway_385 REACTOME_FACTORS_INVOLVED_IN_MEGAKARYOCYTE_DEVELOPMENT_AND_PLATELET_PRODUCTION 0 0.07
Category members GO Category GO:0007006 mitochondrial membrane organization Database 0
Category members GO Category GO:0048593 camera-type eye morphogenesis Database 0
Category members GO Category GO:0048662 negative regulation of smooth muscle cell proliferation Database 0
Category members GO Category GO:0051646 mitochondrion localization Database 0


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