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Query: MDH1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MDH1 0 2.963 0.340 -0.770 1.386 0.112

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MDH1 Ubiquitylation K121 1.157 0.308 _DLLK(gl)ANVK_
MDH1 Ubiquitylation K254 -0.543 _GAAVIK(gl)AR_
MDH1 Ubiquitylation K160 -1.596 _VIVVGNPANTNCLTASK(gl)SAPSIPK_
MDH1 Ubiquitylation K232 -0.046 _EVGVYEALK(gl)DDSWLK_
MDH1 Ubiquitylation K238 -0.272 _EVGVYEALK(gl)DDSWLK_
MDH1 Ubiquitylation K330 0.073 _EK(gl)MDLTAK_

Background Information for MDH1:


Pubmed-MDH1 »
Uniprot-MDH1 »
Biogrid-MDH1 »
ProteomicsDB-MDH1 »

Tumorportal-MDH1 »
COSMIC-MDH1 »
GenomeRNAi-MDH1 »
Genecards-MDH1


Protein-protein Interactions for MDH1
Show screen data for Category Name and Description Link to cat description Data Source


Protein Domains in MDH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Lactate/malate_DH_N IPR001236 0.19
Category members L-lactate/malate_DH IPR001557 0.19
Category members Lactate_DH/Glyco_Ohase_4_C IPR015955 0.04
Category members Lactate/malate_DH_C IPR022383 0.04


Protein complexes (CORUM database) featuring MDH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MDH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members Pathway Pathway_3 KEGG_CITRATE_CYCLE_TCA_CYCLE 0 3.83
Category members GO Category GO:0006099 tricarboxylic acid cycle Database 2.74
Category members Pathway Pathway_35 REACTOME_GLUCOSE_METABOLISM 0 1.79
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members GO Category GO:0051287 NAD binding Database 1.6
Category members GO Category GO:0006094 gluconeogenesis Database 1.42
Category members Pathway Pathway_33 REACTOME_GLUCONEOGENESIS 0 1.41
Category members Pathway Pathway_8 BIOCARTA_KREB_PATHWAY 0 1.35
Category members Pathway Pathway_16 KEGG_PYRUVATE_METABOLISM 0 1.34
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0044262 cellular carbohydrate metabolic process Database 0.64
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_34 REACTOME_METABOLISM_OF_CARBOHYDRATES 0 0.31
Category members GO Category GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Database 0.29
Category members GO Category GO:0006006 glucose metabolic process Database 0.28
Category members GO Category GO:0006734 NADH metabolic process Database 0.26
Category members GO Category GO:0030060 L-malate dehydrogenase activity Database 0.2
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members Pathway Pathway_7 KEGG_GLYOXYLATE_AND_DICARBOXYLATE_METABOLISM 0 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members Pathway Pathway_36 KEGG_PROXIMAL_TUBULE_BICARBONATE_RECLAMATION 0 0
Category members GO Category GO:0004470 malic enzyme activity Database 0
Category members GO Category GO:0006107 oxaloacetate metabolic process Database 0
Category members GO Category GO:0006108 malate metabolic process Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0016615 malate dehydrogenase activity Database 0
Category members GO Category GO:0019674 NAD metabolic process Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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