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Query: MCPH1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MCPH1 0 -0.404 -0.270 -0.170

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MCPH1 Phosphorylation S333 -0.272 0.038 _YRLS(ph)PTLSSTK_
MCPH1 Phosphorylation T335 -0.306 _YRLSPT(ph)LSSTK_

Background Information for MCPH1:


Pubmed-MCPH1 »
Uniprot-MCPH1 »
Biogrid-MCPH1 »
ProteomicsDB-MCPH1 »

Tumorportal-MCPH1 »
COSMIC-MCPH1 »
GenomeRNAi-MCPH1 »
Genecards-MCPH1


Protein-protein Interactions for MCPH1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait EFCAB4B Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MCPH1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members BRCT_dom IPR001357 1.59
Category members BRCA1 IPR011364 0


Protein complexes (CORUM database) featuring MCPH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MCPH1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0005815 microtubule organizing center Database 0.39
Category members GO Category GO:0021987 cerebral cortex development Database 0.37
Category members GO Category GO:0000132 establishment of mitotic spindle orientation Database 0.29
Category members GO Category GO:0042802 identical protein binding Database 0.26
Category members GO Category GO:0046605 regulation of centrosome cycle Database 0.24
Category members GO Category GO:0060623 regulation of chromosome condensation Database 0.24
Category members Disease phenotype Autosomal_recessive_primary_microcephaly Autosomal recessive primary microcephaly Database 0
Category members GO Category GO:0010468 regulation of gene expression Database 0
Category members GO Category GO:0043549 regulation of kinase activity Database 0


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