bioLOGIC Data » bioLOGIC CategoryView » bioLOGIC VennView » Experimental Details »

bioLOGIC Data

bioLOGIC Data


Exact search


Query: MBD1

This is a cancer-associated gene according to the Broad cancer gene census.

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
W
[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MBD1 0 -0.427 0.490 -0.120 -0.298

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MBD1 Phosphorylation S362 -0.412 -0.135 _ALAPS(ph)PPAEFIYYCVDEDELQPYTNRR_
MBD1 Phosphorylation T621 -0.248 _LAPEEEAGGAGT(ph)PVITEIFSLGGTR_
MBD1 Ubiquitylation K110 0.094 _AHPVAVASK(gl)K_
MBD1 Ubiquitylation K111 0.094 _AHPVAVASK(gl)K_
MBD1 Ubiquitylation K434 0.418 _QCLQFAMK(gl)R_

Background Information for MBD1:


Pubmed-MBD1 »
Uniprot-MBD1 »
Biogrid-MBD1 »
ProteomicsDB-MBD1 »

Tumorportal-MBD1 »
COSMIC-MBD1 »
GenomeRNAi-MBD1 »
Genecards-MBD1


Protein-protein Interactions for MBD1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait KIF20A Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF2C Cat. description Hein, Mann, Cell 2015


Protein Domains in MBD1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Methyl_CpG_DNA-bd IPR001739 0
Category members Znf_CXXC IPR002857 0
Category members DNA-bd_dom IPR016177 0


Protein complexes (CORUM database) featuring MBD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 2763 MBD1-Suv39h1-HP1 complex Database 0.05
Category members Corum 2233 Replication-coupled CAF-1-MBD1-ETDB1 complex Database 0
Category members Corum 2238 MBD1-MCAF1-SETDB1 complex Database 0
Category members Corum 2759 MBD1-MCAF complex Database 0


Categories featuring MBD1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000792 heterochromatin Database 5.45
Category members GO Category GO:0016607 nuclear speck Database 4.84
Category members GO Category GO:0005694 chromosome Database 3.87
Category members GO Category GO:0000785 chromatin Database 2.59
Category members GO Category GO:0016363 nuclear matrix Database 1.89
Category members GO Category GO:0003677 DNA binding Database 1.53
Category members GO Category GO:0045892 negative regulation of transcription, DNA-dependent Database 1.15
Category members Human mutations Broad_cancer_genes Broad cancer genes (Lawrence et al., 2014) literature 1.14
Category members GO Category GO:0006366 transcription from RNA polymerase II promoter Database 0.96
Category members GO Category GO:0003700 sequence-specific DNA binding transcription factor activity Database 0.63
Category members GO Category GO:0008327 methyl-CpG binding Database 0.52
Category members GO Category GO:0008270 zinc ion binding Database 0.29
Category members GO Category GO:0003714 transcription corepressor activity Database 0


.

© Copyright Svejstrup Laboratory 2015