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Query: MASTL

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MASTL 0 -1.272 0.400 -0.110 -0.766 0.090

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MASTL Phosphorylation S370 0.034 0.079 _KDLELALS(ph)PIHNSSALPTTGR_
MASTL Phosphorylation T618 -0.221 _ESSFEESNIEDPLIVTPDCQEKT(ph)SPK_
MASTL Phosphorylation S619 -0.221 _ESSFEESNIEDPLIVTPDCQEKT(ph)SPK_
MASTL Phosphorylation S453 -0.863 -0.537 _NFELVDSS(ph)PCKK_
MASTL Ubiquitylation K350 -0.870 _LCAK(gl)SANAIETK_
MASTL Ubiquitylation K266 -0.911 _DTTPYSSK(gl)LLK_
MASTL Ubiquitylation K456 -0.960 _NFELVDSSPCK(gl)K_
MASTL Ubiquitylation K457 -0.960 _NFELVDSSPCK(gl)K_
MASTL Phosphorylation T611 0.195 _ESSFEESNIEDPLIVT(ph)PDCQEKTSPK_

Background Information for MASTL:


Pubmed-MASTL »
Uniprot-MASTL »
Biogrid-MASTL »
ProteomicsDB-MASTL »

Tumorportal-MASTL »
COSMIC-MASTL »
GenomeRNAi-MASTL »
Genecards-MASTL


Protein-protein Interactions for MASTL
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait MASTL Cat. description Hein, Mann, Cell 2015
Category members IP bait PRKCI Cat. description Hein, Mann, Cell 2015
Category members IP bait C16orf70 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MASTL
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Kinase-like_dom IPR011009 0.03
Category members Prot_kinase_dom IPR000719 0
Category members Ser-Thr/Tyr_kinase_cat_dom IPR001245 0
Category members Ser/Thr_dual-sp_kinase IPR002290 0
Category members Tyr_kinase_cat_dom IPR020635 0


Protein complexes (CORUM database) featuring MASTL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MASTL
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005654 nucleoplasm Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0000278 mitotic cell cycle Database 10.63
Category members GO Category GO:0005524 ATP binding Database 5.54
Category members GO Category GO:0006974 cellular response to DNA damage stimulus Database 3.57
Category members GO Category GO:0007067 mitosis Database 2.23
Category members GO Category GO:0032154 cleavage furrow Database 2.01
Category members GO Category GO:0005813 centrosome Database 0.75
Category members GO Category GO:0004674 protein serine/threonine kinase activity Database 0.66
Category members GO Category GO:0000086 G2/M transition of mitotic cell cycle Database 0.33
Category members GO Category GO:0016301 kinase activity Database 0.23
Category members GO Category GO:0004672 protein kinase activity Database 0.19
Category members GO Category GO:0051726 regulation of cell cycle Database 0.11
Category members Disease phenotype Autosomal_thrombocytopenia_with_normal_platelets Autosomal thrombocytopenia with normal platelets Database 0.08
Category members GO Category GO:0006468 protein phosphorylation Database 0.04
Category members GO Category GO:0004713 protein tyrosine kinase activity Database 0.01
Category members Disease phenotype THROMBOCYTOPENIA_2 THROMBOCYTOPENIA 2 Database 0
Category members GO Category GO:0016772 transferase activity, transferring phosphorus-containing groups Database 0
Category members GO Category GO:0034048 negative regulation of protein phosphatase type 2A activity Database 0
Category members GO Category GO:0051721 protein phosphatase 2A binding Database 0


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