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Query: MACF1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
MACF1 1 3.470 -0.599
MACF1 1 3.470 -0.173 -0.431
MACF1 1 3.470 0.796 0.236
MACF1 1 3.470 0.244 0.182 0.206

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
MACF1 Phosphorylation S5733 1.034 _EVEEELATSGGQS(ph)PTGEQIPQFQQR_
MACF1 Phosphorylation S3959 1.328 0.973 _RQGS(ph)FSEDVISHK_
MACF1 Phosphorylation S3961 0.813 _RQGS(ph)FSEDVISHK_
MACF1 Phosphorylation S312 1.509 0.797 _LLDAEDVDVPS(ph)PDEK_
MACF1 Phosphorylation T5728 0.246 0.783 _EVEEELAT(ph)SGGQSPTGEQIPQFQQR_
MACF1 Phosphorylation S4528 0.586 -0.026 _SMDAMSS(ph)PTKTETVK_
MACF1 Phosphorylation S1399 -0.230 -0.113 _AFVESQQKS(ph)PGK_
MACF1 Phosphorylation S4553 0.011 -0.229 _AFLAELEQNS(ph)PK_
MACF1 Phosphorylation S7105 -1.286 -1.582 _S(ph)LSQPTPPPMPILSQSEAK_
MACF1 Ubiquitylation K189 -0.349 _AVLLPLQGETAVEK(gl)GNIQR_
MACF1 Phosphorylation S4527 0.479 _SMDAM(ox)S(ph)SPTKTETVK_

Background Information for MACF1:


Pubmed-MACF1 »
Uniprot-MACF1 »
Biogrid-MACF1 »
ProteomicsDB-MACF1 »

Tumorportal-MACF1 »
COSMIC-MACF1 »
GenomeRNAi-MACF1 »
Genecards-MACF1


Protein-protein Interactions for MACF1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait BAG6;BAT3 Cat. description Hein, Mann, Cell 2015
Category members IP bait BATF3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CALML3 Cat. description Hein, Mann, Cell 2015
Category members IP bait CAPZA2 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDH1 Cat. description Hein, Mann, Cell 2015
Category members IP bait CNOT2 Cat. description Hein, Mann, Cell 2015
Category members IP bait DAXX Cat. description Hein, Mann, Cell 2015
Category members IP bait KIAA1107 Cat. description Hein, Mann, Cell 2015
Category members IP bait MAD2L1 Cat. description Hein, Mann, Cell 2015
Category members IP bait MYH9 Cat. description Hein, Mann, Cell 2015
Category members IP bait NDC80 Cat. description Hein, Mann, Cell 2015
Category members IP bait SASS6 Cat. description Hein, Mann, Cell 2015
Category members IP bait SYNCRIP Cat. description Hein, Mann, Cell 2015
Category members IP bait WIPI2 Cat. description Hein, Mann, Cell 2015
Category members IP bait ALX3 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait AMMECR1L Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait CDKL5 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait ID2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MAPRE1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait MTUS2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait SNAP29 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in MACF1
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Spectrin_repeat IPR002017 2.4
Category members Spectrin/alpha-actinin IPR018159 1.6
Category members CH-domain IPR001715 0.63
Category members CAMSAP_CH IPR022613 0.13
Category members Plectin_repeat IPR001101 0.1
Category members EF_hand_dom IPR002048 0
Category members GAS2_dom IPR003108 0
Category members RNaseH-like_dom IPR012337 0


Protein complexes (CORUM database) featuring MACF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring MACF1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0003779 actin binding Database 5.41
Category members DDR Literature pubmedid:19647519 Paulsen et al., 2009 siRNA screen for g-H2A.x phosphorylation 3.6
Category members GO Category GO:0016887 ATPase activity Database 2.28
Category members GO Category GO:0015629 actin cytoskeleton Database 2.22
Category members GO Category GO:0006200 ATP catabolic process Database 2.13
Category members GO Category GO:0015630 microtubule cytoskeleton Database 1.34
Category members GO Category GO:0005874 microtubule Database 1.21
Category members GO Category GO:0005886 plasma membrane Database 1.21
Category members GO Category GO:0007163 establishment or maintenance of cell polarity Database 1.08
Category members GO Category GO:0051015 actin filament binding Database 0.99
Category members GO Category GO:0006620 posttranslational protein targeting to membrane Database 0.93
Category members GO Category GO:0003676 nucleic acid binding Database 0.83
Category members GO Category GO:0008017 microtubule binding Database 0.79
Category members GO Category GO:0032587 ruffle membrane Database 0.65
Category members GO Category GO:0005856 cytoskeleton Database 0.63
Category members GO Category GO:0043001 Golgi to plasma membrane protein transport Database 0.32
Category members GO Category GO:0032886 regulation of microtubule-based process Database 0.29
Category members GO Category GO:0005794 Golgi apparatus Database 0.27
Category members GO Category GO:0006928 cellular component movement Database 0.24
Category members GO Category GO:0001707 mesoderm formation Database 0.11
Category members GO Category GO:0005509 calcium ion binding Database 0.11
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0007050 cell cycle arrest Database 0
Category members GO Category GO:0030177 positive regulation of Wnt signaling pathway Database 0
Category members GO Category GO:0042060 wound healing Database 0
Category members GO Category GO:0051893 regulation of focal adhesion assembly Database 0


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