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Query: LGMN

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LGMN 0 3.110 -0.120 0.250 0.435 0.710

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LGMN Ubiquitylation K287 1.040 _VMQFQGMK(gl)R_
LGMN Ubiquitylation K224 0.675 0.933 _ESSYACYYDEK(gl)R_
LGMN Ubiquitylation K125 0.264 -0.241 _GDAEAVK(gl)GIGSGK_

Background Information for LGMN:


Pubmed-LGMN »
Uniprot-LGMN »
Biogrid-LGMN »
ProteomicsDB-LGMN »

Tumorportal-LGMN »
COSMIC-LGMN »
GenomeRNAi-LGMN »
Genecards-LGMN


Protein-protein Interactions for LGMN
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait C14ORF10;PPP2R3C Cat. description Hein, Mann, Cell 2015
Category members IP bait DCTN3 Cat. description Hein, Mann, Cell 2015
Category members IP bait RNASEH2A Cat. description Hein, Mann, Cell 2015
Category members IP bait SOD1 Cat. description Hein, Mann, Cell 2015
Category members IP bait YWHAH Cat. description Hein, Mann, Cell 2015
Category members IP bait DEFA1 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait LGMN Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LGMN
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Peptidase_C13 IPR001096 0.05


Protein complexes (CORUM database) featuring LGMN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring LGMN
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Pathway Pathway_621 REACTOME_ADAPTIVE_IMMUNE_SYSTEM 0 4.72
Category members Pathway Pathway_458 REACTOME_IMMUNE_SYSTEM 0 3
Category members GO Category GO:0043524 negative regulation of neuron apoptotic process Database 0.66
Category members Pathway Pathway_1265 REACTOME_MHC_CLASS_II_ANTIGEN_PRESENTATION 0 0.6
Category members GO Category GO:0004197 cysteine-type endopeptidase activity Database 0.38
Category members GO Category GO:0003014 renal system process Database 0.35
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members Pathway Pathway_460 REACTOME_INNATE_IMMUNE_SYSTEM 0 0.29
Category members Pathway Pathway_527 REACTOME_TOLL_RECEPTOR_CASCADES 0 0.17
Category members GO Category GO:0019886 antigen processing and presentation of exogenous peptide antigen via MHC class II Database 0.13
Category members GO Category GO:0002224 toll-like receptor signaling pathway Database 0.12
Category members Pathway Pathway_767 KEGG_ANTIGEN_PROCESSING_AND_PRESENTATION 0 0.09
Category members GO Category GO:0005770 late endosome Database 0.09
Category members GO Category GO:0043202 lysosomal lumen Database 0.07
Category members GO Category GO:0045087 innate immune response Database 0.05
Category members GO Category GO:0008233 peptidase activity Database 0.02
Category members Pathway Pathway_1269 REACTOME_TRAFFICKING_AND_PROCESSING_OF_ENDOSOMAL_TLR 0 0
Category members Pathway Pathway_4 REACTOME_METABOLISM_OF_LIPIDS_AND_LIPOPROTEINS 0 0
Category members Pathway Pathway_69 REACTOME_STEROID_HORMONES 0 0
Category members Pathway Pathway_70 REACTOME_METABOLISM_OF_STEROID_HORMONES_AND_VITAMINS_A_AND_D 0 0
Category members Pathway Pathway_74 KEGG_LYSOSOME 0 0
Category members GO Category GO:0001101 response to acid Database 0
Category members GO Category GO:0005764 lysosome Database 0
Category members GO Category GO:0006508 proteolysis Database 0
Category members GO Category GO:0008202 steroid metabolic process Database 0
Category members GO Category GO:0032801 receptor catabolic process Database 0
Category members GO Category GO:0040015 negative regulation of multicellular organism growth Database 0
Category members GO Category GO:0042359 vitamin D metabolic process Database 0
Category members GO Category GO:0045177 apical part of cell Database 0
Category members GO Category GO:0051603 proteolysis involved in cellular protein catabolic process Database 0


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