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Query: LEO1

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LEO1 1 8.584 -0.730 0.200 1.072 0.738 1.390 1.163 0.646

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LEO1 Phosphorylation S14 1.186 _(ac)ADMEDLFGSDADS(ph)EAER_
LEO1 Phosphorylation S10 0.712 _(ac)ADMEDLFGS(ph)DADSEAER_
LEO1 Phosphorylation T629 0.613 _KLT(ph)SDEEGEPSGK_
LEO1 Phosphorylation S630 0.373 0.499 _LTS(ph)DEEGEPSGK_
LEO1 Phosphorylation S658 0.549 0.449 _YVIS(ph)DEEEEDDD_
LEO1 Ubiquitylation K415 1.075 _LK(gl)VENTIR_
LEO1 Ubiquitylation K486 1.353 _QGTGLQGQAVFK(gl)TK_
LEO1 Ubiquitylation K503 1.640 _K(gl)MTLSLADR_
LEO1 Ubiquitylation K537 0.452 _TEMIK(gl)KEEER_

Background Information for LEO1:


Pubmed-LEO1 »
Uniprot-LEO1 »
Biogrid-LEO1 »
ProteomicsDB-LEO1 »

Tumorportal-LEO1 »
COSMIC-LEO1 »
GenomeRNAi-LEO1 »
Genecards-LEO1


Protein-protein Interactions for LEO1
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CDC73 Cat. description Hein, Mann, Cell 2015
Category members IP bait CTR9 Cat. description Hein, Mann, Cell 2015
Category members IP bait LEO1 Cat. description Hein, Mann, Cell 2015
Category members IP bait RPRD1B Cat. description Hein, Mann, Cell 2015
Category members IP bait SUPT5H Cat. description Hein, Mann, Cell 2015
Category members IP bait WDR61 Cat. description Hein, Mann, Cell 2015
Category members IP bait CDC73 Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait HIST1H1E Cat. description BioPlex, Huttlin, Gygi, Cell 2015
Category members IP bait TULP2 Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LEO1
Domain name Domain Description TC-NER relevance -log10(p-value)


Protein complexes (CORUM database) featuring LEO1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members Corum 1167 Paf complex Database 1.75


Categories featuring LEO1
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005634 nucleus Database INF
Category members GO Category GO:0005730 nucleolus Database 13.38
Category members GO Category GO:0001711 endodermal cell fate commitment Database 2.34
Category members GO Category GO:0016593 Cdc73/Paf1 complex Database 1.75
Category members GO Category GO:0010390 histone monoubiquitination Database 1.39
Category members GO Category GO:0006351 transcription, DNA-templated Database 1.07
Category members GO Category GO:0032968 positive regulation of transcription elongation from RNA polymerase II promoter Database 0.99
Category members GO Category GO:0033523 histone H2B ubiquitination Database 0.77
Category members GO Category GO:0031442 positive regulation of mRNA 3'-end processing Database 0.7
Category members GO Category GO:0019827 stem cell maintenance Database 0.48
Category members GO Category GO:0045944 positive regulation of transcription from RNA polymerase II promoter Database 0.13
Category members GO Category GO:0016055 Wnt signaling pathway Database 0.11
Category members GO Category GO:0045638 negative regulation of myeloid cell differentiation Database 0.1
Category members GO Category GO:0006378 mRNA polyadenylation Database 0.1


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