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Query: LDHA

RNAi screen result RNAPII IP (PI) CSB IP CSB IP (PI) Chrom. Chrom. (PI) Phosphorylation Ubiquitylation
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[Click on the plots to view the data selection in the respective scatterplot]

Protein Results:

 Results for post-translational modifications: see below | Red/green: hit at lower/upper end of the respective screen
Gene name Point score Z-score sums RNAi high RNAi low RNAPII-IP (PI) CSB-IP CSB-IP (PI) Chrom. Chrom. (PI)
LDHA 1 0.497 0.290 0.240 0.385 2.314 -1.710 0.736 -1.948

PTM Sites:

 Back to Protein Results | Red/green: hit at lower/upper end of the respective screen
Gene name PTM type PTM site UV UV (PI) Sequence
LDHA Ubiquitylation K81 -0.222 0.603 _IVSGK(gl)DYNVTANSK_
LDHA Ubiquitylation K76 0.117 0.016 _TPK(gl)IVSGKDYNVTANSK_
LDHA Ubiquitylation K318 -0.423 -0.142 _K(gl)SADTLWGIQK_
LDHA Ubiquitylation K126 -1.139 -0.426 _FIIPNVVK(gl)YSPNCK_
LDHA Ubiquitylation K14 -1.168 _DQLIYNLLK(gl)EEQTPQNK_
LDHA Ubiquitylation K118 -0.092 _NVNIFK(gl)FIIPNVVK_
LDHA Ubiquitylation K317 0.038 _LK(gl)KSADTLWGIQK_

Background Information for LDHA:


Pubmed-LDHA »
Uniprot-LDHA »
Biogrid-LDHA »
ProteomicsDB-LDHA »

Tumorportal-LDHA »
COSMIC-LDHA »
GenomeRNAi-LDHA »
Genecards-LDHA


Protein-protein Interactions for LDHA
Show screen data for Category Name and Description Link to cat description Data Source
Category members IP bait CKAP5 Cat. description Hein, Mann, Cell 2015
Category members IP bait ERCC6L Cat. description Hein, Mann, Cell 2015
Category members IP bait KIF11 Cat. description Hein, Mann, Cell 2015
Category members IP bait PANK4 Cat. description Hein, Mann, Cell 2015
Category members IP bait LDHA Cat. description BioPlex, Huttlin, Gygi, Cell 2015


Protein Domains in LDHA
Domain name Domain Description TC-NER relevance -log10(p-value)
Category members Lactate/malate_DH_N IPR001236 0.19
Category members L-lactate/malate_DH IPR001557 0.19
Category members L-lactate_DH IPR011304 0.08
Category members Lactate_DH/Glyco_Ohase_4_C IPR015955 0.04
Category members Lactate/malate_DH_C IPR022383 0.04


Protein complexes (CORUM database) featuring LDHA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)


Categories featuring LDHA
Category Type Category ID Category Name Data Source TC-NER relevance -log10(p-value)
Category members DDR Literature pubmedid:24332808 Marechal et al., 2014 RPA-mediated recruitment INF
Category members GO Category GO:0005515 protein binding Database INF
Category members GO Category GO:0005829 cytosol Database INF
Category members GO Category GO:0005737 cytoplasm Database 12.81
Category members GO Category GO:0006096 glycolysis Database 2.49
Category members Pathway Pathway_28 KEGG_PROPANOATE_METABOLISM 0 1.89
Category members Pathway Pathway_10 REACTOME_PYRUVATE_METABOLISM_AND_CITRIC_ACID_TCA_CYCLE 0 1.76
Category members GO Category GO:0005739 mitochondrion Database 1.67
Category members Pathway Pathway_16 KEGG_PYRUVATE_METABOLISM 0 1.34
Category members Pathway Pathway_65 PID_MYC_ACTIV_PATHWAY 0 1.08
Category members Pathway Pathway_402 BIOCARTA_SARS_PATHWAY 0 0.64
Category members GO Category GO:0044262 cellular carbohydrate metabolic process Database 0.64
Category members GO Category GO:0044281 small molecule metabolic process Database 0.35
Category members GO Category GO:0016616 oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor Database 0.29
Category members Pathway Pathway_52 PID_HIF1_TFPATHWAY 0 0.11
Category members GO Category GO:0003824 catalytic activity Database 0.11
Category members GO Category GO:0004459 L-lactate dehydrogenase activity Database 0.08
Category members GO Category GO:0044237 cellular metabolic process Database 0.08
Category members GO Category GO:0005975 carbohydrate metabolic process Database 0.07
Category members Pathway Pathway_14 REACTOME_PYRUVATE_METABOLISM 0 0.05
Category members Pathway Pathway_13 REACTOME_TCA_CYCLE_AND_RESPIRATORY_ELECTRON_TRANSPORT 0 0.04
Category members GO Category GO:0006090 pyruvate metabolic process Database 0.04
Category members Pathway Pathway_400 KEGG_CYSTEINE_AND_METHIONINE_METABOLISM 0 0.04
Category members Pathway Pathway_407 BIOCARTA_HIF_PATHWAY 0 0
Category members GO Category GO:0005929 cilium Database 0
Category members GO Category GO:0016491 oxidoreductase activity Database 0
Category members GO Category GO:0031668 cellular response to extracellular stimulus Database 0
Category members GO Category GO:0055114 oxidation-reduction process Database 0


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